63315

• Gene Symbol: Nfkb1
• Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
• Gene Aliases: NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105
• Chromosome Location: Chr.3: 135584655 - 135691547 on Build GRCm38
• UniGene ID: Mm.256765
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Nfkb1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008689.2	NP_032715.2	7, 8	894
GenBank mRNA	AB119195.1	-	5, 6	392
	AB221614.1	-	5, 6	399
	AK052726.1	-	2, 3	202
	AY521462.1	-	5, 6	392
	AY521463.1	-	5, 6	392
	BC050841.1	-	7, 8	894
	BC138535.1	-	6, 7	471	8861555
	BC138536.1	-	6, 7	471	8861556
	BC145317.1	-	7, 8	488
	M57999.1	-	7, 8	683

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001276711, XM_006233358, XM_006233360.

Panther Classification:

Molecular Function -

Rel homology transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
negative regulation of cytokine production
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
inflammatory response
response to oxidative stress
signal transduction
I-kappaB kinase/NF-kappaB signaling
negative regulation of calcidiol 1-monooxygenase activity
response to cytokine
response to muscle stretch
NIK/NF-kappaB signaling
negative regulation of apoptotic process
negative regulation of interleukin-12 biosynthetic process
innate immune response
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lymph node development
negative regulation of inflammatory response
cellular response to lipopolysaccharide
cellular response to nicotine
cellular response to interleukin-6
cellular response to dsRNA
cellular response to peptide hormone stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of hyaluronan biosynthetic process
positive regulation of miRNA metabolic process

Function(s)

regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
heat shock protein binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity