63333

• Gene Symbol: Nos3
• Gene Name: nitric oxide synthase 3, endothelial cell
• Gene Aliases: 2310065A03Rik, Nos-3, eNOS, ecNOS
• Chromosome Location: Chr.5: 24364819 - 24384474 on Build GRCm38
• UniGene ID: Mm.258415
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Nos3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008713.4	NP_032739.3	4, 5	606
GenBank mRNA	AK077896.1	-	4, 5	608
	AK143221.1	-	3, 4	378
	AK158106.1	-	4, 5	619
	BC052636.1	-	4, 5	593	6530765
	U53142.1	-	4, 5	594

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_021838, XM_006235872, AY695391, AB176831, AF085195.

Panther Classification:

Molecular Function -

oxidoreductase

Gene Ontology Categories:

Process(es)

angiogenesis
ovulation from ovarian follicle
in utero embryonic development
blood vessel remodeling
regulation of sodium ion transport
regulation of the force of heart contraction by chemical signal
regulation of systemic arterial blood pressure by endothelin
arginine catabolic process
nitric oxide biosynthetic process
signal transduction
nitric oxide mediated signal transduction
negative regulation of cell proliferation
negative regulation of muscle hyperplasia
smooth muscle hyperplasia
lung development
positive regulation of guanylate cyclase activity
lipopolysaccharide-mediated signaling pathway
response to estradiol
positive regulation of apoptotic process
negative regulation of potassium ion transport
endothelial cell migration
positive regulation of angiogenesis
negative regulation of blood pressure
positive regulation of vasodilation
negative regulation of smooth muscle cell proliferation
regulation of blood vessel size
negative regulation of hydrolase activity
negative regulation of calcium ion transport
oxidation-reduction process
cellular response to mechanical stimulus
cellular response to transforming growth factor beta stimulus

Function(s)

actin binding
actin monomer binding
NADPH-hemoprotein reductase activity
nitric-oxide synthase activity
iron ion binding
calmodulin binding
beta-catenin binding
FMN binding
oxidoreductase activity
heme binding
tetrahydrobiopterin binding
arginine binding
cadherin binding
metal ion binding
flavin adenine dinucleotide binding
NADP binding
nitric-oxide synthase binding
Hsp90 protein binding
scaffold protein binding