644 Validated

• Gene Symbol: EGFR
• Gene Name: epidermal growth factor receptor
• Gene Aliases: ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
• Chromosome Location: Chr.7: 55019032 - 55207338 on Build GRCh38
• UniGene ID: Hs.488293
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: EGFR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005228.3	NP_005219.2	2	351
	NM_201282.1	NP_958439.1	2	351
	NM_201283.1	NP_958440.1	2	351
	NM_201284.1	NP_958441.1	2	351
GenBank mRNA	AB209442.1	-	2	251
	AF125253.1	-	2	350
	AK225422.1	-	2	266
	AK290352.1	-	2	151
	AK294750.1	-	2	129
	AW163038.1	-	2	351
	AY698023.1	-	2	105
	AY698024.1	-	2	105
	BC094761.1	-	2	362	30528231
	DQ088980.1	-	2	151
	GU255993.1	-	2	148
	HQ912715.1	-	2	351
	K03193.1	-	2	264
	U48722.1	-	2	349
	U95089.1	-	3	608
	X00588.1	-	2	291

More Information

Matching Taqman Gene Expression Assay:

Hs00193306_m1

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
cell morphogenesis
ossification
embryonic placenta development
positive regulation of protein phosphorylation
hair follicle development
response to stress
signal transduction
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
activation of phospholipase C activity
salivary gland morphogenesis
learning or memory
cell proliferation
positive regulation of cell proliferation
regulation of phosphatidylinositol 3-kinase signaling
single organismal cell-cell adhesion
peptidyl-tyrosine phosphorylation
cerebral cortex cell migration
positive regulation of cell growth
positive regulation of cell migration
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
positive regulation of catenin import into nucleus
ERBB2 signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of phosphorylation
activation of phospholipase A2 activity by calcium-mediated signaling
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of nitric oxide biosynthetic process
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
digestive tract morphogenesis
positive regulation of epithelial cell proliferation
regulation of peptidyl-tyrosine phosphorylation
regulation of nitric-oxide synthase activity
protein insertion into membrane
positive regulation of protein kinase B signaling
morphogenesis of an epithelial fold
eyelid development in camera-type eye
response to UV-A
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
positive regulation of production of miRNAs involved in gene silencing by miRNA
regulation of cell motility

Function(s)

chromatin binding
double-stranded DNA binding
MAP kinase kinase kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane signaling receptor activity
epidermal growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
enzyme binding
protein phosphatase binding
nitric-oxide synthase regulator activity
ubiquitin protein ligase binding
identical protein binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion