65467

• Gene Symbol: Adam17
• Gene Name: a disintegrin and metallopeptidase domain 17
• Gene Aliases: CD156b, Tace
• Chromosome Location: Chr.12: 21323509 - 21373632 on Build GRCm38
• UniGene ID: Mm.27681
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Adam17
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001277266.1	NP_001264195.1	2	375
	NM_001291871.1	NP_001278800.1	2	375
	NM_009615.6	NP_033745.4	2	375
GenBank mRNA	AB021709.1	-	2	336
	AJ007365.1	-	2	175
	AK137693.1	-	2	282
	AK139471.1	-	2	281
	AK142441.1	-	2	315
	AK144161.1	-	2	305
	AK149288.1	-	2	278
	AK149614.1	-	2	282
	AK165739.1	-	2	282
	BC048792.1	-	2	283
	BC094655.1	-	2	289	5705503
	BC114999.1	-	2	235	6506501
	BC138416.1	-	2	254	8861436
	BC138420.1	-	2	254	8861440
	BC145270.1	-	2	254	9053824
	CA325381.1	-	2	343
	U69613.1	-	2	243
	U69614.1	-	2	327

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_020306, AJ012603.

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

response to hypoxia
positive regulation of protein phosphorylation
germinal center formation
proteolysis
membrane protein ectodomain proteolysis
cell adhesion
epidermal growth factor receptor signaling pathway
Notch signaling pathway
Notch receptor processing
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
B cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
response to lipopolysaccharide
positive regulation of chemokine production
regulation of mast cell apoptotic process
T cell differentiation in thymus
cell adhesion mediated by integrin
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
response to drug
negative regulation of apoptotic process
positive regulation of epidermal growth factor-activated receptor activity
spleen development
cell motility
defense response to Gram-positive bacterium
PMA-inducible membrane protein ectodomain proteolysis
positive regulation of cellular component movement
response to high density lipoprotein particle

Function(s)

metalloendopeptidase activity
Notch binding
interleukin-6 receptor binding
integrin binding
protein binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
SH3 domain binding
PDZ domain binding
metal ion binding