65892

• Gene Symbol: Apex1
• Gene Name: apurinic/apyrimidinic endonuclease 1
• Gene Aliases: APE, Apex, HAP1, Ref-1
• Chromosome Location: Chr.14: 50924944 - 50927188 on Build GRCm38
• UniGene ID: Mm.203
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Apex1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_009687.2	NP_033817.1	5	816
GenBank mRNA	AK013296.1	-	5	784
	AK178250.1	-	1	177
	AK212859.1	-	1	216
	BC052401.1	-	5	787	5715485
	D90374.1	-	4	744

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_024148, XM_006251913, L27076, AF309114, BC078816, and others.

Gene Ontology Categories:

Process(es)

DNA repair
base-excision repair
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
aging
negative regulation of smooth muscle cell migration
regulation of mRNA stability
cell redox homeostasis
positive regulation of DNA repair
oxidation-reduction process
cellular response to hydrogen peroxide
DNA demethylation
nucleic acid phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis, endonucleolytic
positive regulation of G1/S transition of mitotic cell cycle
regulation of nucleic acid-templated transcription

Function(s)

DNA binding
damaged DNA binding
transcription coactivator activity
RNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
nuclease activity
endonuclease activity
endoribonuclease activity
exonuclease activity
double-stranded DNA 3'-5' exodeoxyribonuclease activity
3'-5' exonuclease activity
oxidoreductase activity
hydrolase activity
lyase activity
site-specific endodeoxyribonuclease activity, specific for altered base
chromatin DNA binding
protein complex binding
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
poly(A) RNA binding
retroviral 3' processing activity
metal ion binding
NF-kappaB binding