66129

• Gene Symbol: Cdkn2a
• Gene Name: cyclin-dependent kinase inhibitor 2A
• Gene Aliases: ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF
• Chromosome Location: Chr.4: 89274473 - 89294619 on Build GRCm38
• UniGene ID: Mm.4733
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Cdkn2a
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001040654.1	NP_001035744.1	1, 2	215
	NM_009877.2	NP_034007.1	1, 2	294
GenBank mRNA	AB221638.1	-	1, 2	199
	AF044335.1	-	1, 2	215
	AF044336.1	-	1, 2	215
	AK155307.1	-	1, 2	204
	BC058190.1	-	1, 2	214	5342027
	EU071702.1	-	1, 2	66
	L76092.1	-	1, 2	240
	L76150.1	-	1, 2	212
	S80650.1	-	1, 2	240

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_031550, AF474976, AY679727, AF474975, AY679728, and others.

Gene Ontology Categories:

Process(es)

regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
protein polyubiquitination
mitophagy
negative regulation of cell-matrix adhesion
transcription, DNA-templated
regulation of transcription, DNA-templated
rRNA processing
negative regulation of protein kinase activity
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle
cell cycle arrest
aging
cell aging
negative regulation of cell proliferation
epidermis development
apoptotic mitochondrial changes
rRNA transcription
response to organonitrogen compound
regulation of G2/M transition of mitotic cell cycle
regulation of gene expression
response to organic cyclic compound
negative regulation of cell growth
negative regulation of B cell proliferation
regulation of protein stability
protein destabilization
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein binding
negative regulation of immature T cell proliferation in thymus
positive regulation of protein sumoylation
negative regulation of mammary gland epithelial cell proliferation
positive regulation of smooth muscle cell apoptotic process
somatic stem cell population maintenance
senescence-associated heterochromatin focus assembly
negative regulation of phosphorylation
response to drug
glucose homeostasis
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleocytoplasmic transport
regulation of protein export from nucleus
somatic stem cell division
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of ubiquitin-protein transferase activity
mitochondrial depolarization
positive regulation of apoptotic process involved in mammary gland involution
cellular response to hydrogen peroxide
protein K63-linked ubiquitination
positive regulation of cell cycle arrest
cellular senescence
replicative senescence
positive regulation of protein localization to nucleus
positive regulation of signal transduction by p53 class mediator
regulation of apoptotic DNA fragmentation
negative regulation of proteolysis involved in cellular protein catabolic process
regulation of protein targeting to mitochondrion
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of macrophage apoptotic process
positive regulation of cellular senescence

Function(s)

p53 binding
DNA binding
transcription factor activity, sequence-specific DNA binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
transcription factor binding
protein kinase binding
poly(A) RNA binding
protein N-terminus binding
NF-kappaB binding
ubiquitin-protein transferase inhibitor activity
MDM2/MDM4 family protein binding