669

• Gene Symbol: LCK
• Gene Name: LCK proto-oncogene, Src family tyrosine kinase
• Gene Aliases: IMD22, LSK, YT16, p56lck, pp58lck
• Chromosome Location: Chr.1: 32251239 - 32286167 on Build GRCh38
• UniGene ID: Hs.470627
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: LCK
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001042771.2	NP_001036236.1	7	657
	NM_005356.4	NP_005347.3	7	674
	XM_011541453.2	XP_011539755.1	6	848
	XM_011541454.2	XP_011539756.1	6	829
	XM_011541455.2	XP_011539757.1	7	674
GenBank mRNA	AF228313.1	-	6	497
	AJ865079.1	-	5	710
	AK098027.1	-	7	471
	AK303073.1	-	6	727
	BC013200.1	-	7	636	4341278
	KU178161.1	-	6	536
	KU178162.1	-	6	536
	KU178163.1	-	6	536
	M36881.1	-	7	587
	U07236.1	-	7	562
	X05027.1	-	7	628
	X13529.1	-	7	587

More Information

Gene Ontology Categories:

Process(es)

protein phosphorylation
protein dephosphorylation
cellular zinc ion homeostasis
activation of cysteine-type endopeptidase activity involved in apoptotic process
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
viral process
hemopoiesis
platelet activation
T cell differentiation
T cell costimulation
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
response to drug
innate immune response
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
regulation of defense response to virus by virus
T cell receptor signaling pathway
B cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of T cell activation
leukocyte migration
release of sequestered calcium ion into cytosol
regulation of lymphocyte activation
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

glycoprotein binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein serine/threonine phosphatase activity
protein binding
ATP binding
protein C-terminus binding
kinase activity
protein kinase binding
protein phosphatase binding
SH2 domain binding
CD4 receptor binding
CD8 receptor binding
identical protein binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
ATPase binding