67810

• Gene Symbol: Irs1
• Gene Name: insulin receptor substrate 1
• Gene Aliases: G972R, IRS-1
• Chromosome Location: Chr.1: 82233105 - 82291439 on Build GRCm38
• UniGene ID: Mm.4952
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Irs1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010570.4	NP_034700.2	2	5246
GenBank mRNA	AK045317.1	-	2	5225
	AK052241.1	-	1	69
	AK136875.1	-	1	347
	X69722.1	-	2	4769

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012969, X58375.

Gene Ontology Categories:

Process(es)

positive regulation of mesenchymal cell proliferation
signal transduction
insulin receptor signaling pathway
regulation of gene expression
positive regulation of glucose metabolic process
phosphatidylinositol 3-kinase signaling
lipid catabolic process
insulin secretion
positive regulation of cell migration
mammary gland development
response to caffeine
positive regulation of fatty acid beta-oxidation
response to insulin
cellular response to insulin stimulus
protein localization to nucleus
positive regulation of phosphorylation
response to peptide hormone
protein kinase B signaling
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
insulin-like growth factor receptor signaling pathway
protein heterooligomerization
positive regulation of glucagon secretion
negative regulation of somatostatin secretion
positive regulation of glucose import in response to insulin stimulus

Function(s)

signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity
protein kinase C binding
insulin receptor binding
insulin-like growth factor receptor binding
protein binding
protein kinase binding
protein domain specific binding
SH2 domain binding
phosphatidylinositol 3-kinase binding