67824

• Gene Symbol: Jak3
• Gene Name: Janus kinase 3
• Gene Aliases: fae, wil
• Chromosome Location: Chr.8: 71676383 - 71690577 on Build GRCm38
• UniGene ID: Mm.249645
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Jak3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001190830.1	NP_001177759.1	10, 11	1649
	NM_010589.6	NP_034719.2	10, 11	1649
GenBank mRNA	AK038268.1	-	9, 10	1460
	AK088365.1	-	10, 11	1498
	AK142178.1	-	10, 11	1487
	AK156646.1	-	10, 11	1471
	AK164520.1	-	10, 11	1489
	BC105577.1	-	9, 10	1452	3968386
	BC131646.1	-	9, 10	1460	40110146
	BC131647.1	-	9, 10	1460	40110148
	L32955.1	-	9, 10	1448
	L33768.1	-	7, 8	2093
	L40172.1	-	10, 11	1510

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012855, XM_008771064, D28508.

Gene Ontology Categories:

Process(es)

immune system process
negative regulation of dendritic cell cytokine production
protein phosphorylation
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cytosolic calcium ion concentration
tyrosine phosphorylation of STAT protein
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
B cell differentiation
erythrocyte differentiation
negative regulation of interleukin-10 production
negative regulation of interleukin-12 production
intracellular signal transduction
interleukin-4-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
tyrosine phosphorylation of Stat5 protein
T cell homeostasis
innate immune response
negative regulation of FasL biosynthetic process
negative regulation of T-helper 1 cell differentiation
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
lymph node development
positive regulation of immune response
negative regulation of T cell activation
positive regulation of calcium ion transport
regulation of T cell apoptotic process
negative regulation of thymocyte apoptotic process
response to interleukin-2
response to interleukin-4
response to interleukin-15
response to interleukin-9
positive regulation of dendritic cell apoptotic process
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphatase binding
hormone receptor binding