6874

• Gene Symbol: TLR4
• Gene Name: toll like receptor 4
• Gene Aliases: ARMD10, CD284, TLR-4, TOLL
• Chromosome Location: Chr.9: 117704175 - 117717491 on Build GRCh38
• UniGene ID: Hs.174312
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TLR4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003266.3	NP_003257.1	4	2492
	NM_138554.4	NP_612564.1	3	2372
	NM_138557.2	NP_612567.1	2	2205
GenBank mRNA	AB445638.1	-	3	2074
	AK226155.1	-	4	2247
	AK290053.1	-	4	2475
	AK293068.1	-	3	2203
	AK303730.1	-	2	2036
	BC025294.1	-	2	1991
	BC117422.1	-	3	2094	40125973
	BC143841.1	-	4	2214
	U69193.1	-	1	75
	U88880.1	-	4	2238
	U93091.1	-	3	2177

More Information

Gene Ontology Categories:

Process(es)

activation of MAPK activity
toll-like receptor signaling pathway
B cell proliferation involved in immune response
nitric oxide production involved in inflammatory response
regulation of dendritic cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
inflammatory response
immune response
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
positive regulation of platelet activation
positive regulation of gene expression
astrocyte development
detection of fungus
positive regulation of B cell proliferation
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
detection of lipopolysaccharide
interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
negative regulation of interleukin-23 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
negative regulation of MyD88-independent toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
T-helper 1 type immune response
macrophage activation
positive regulation of NF-kappaB import into nucleus
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of MHC class II biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of nitric oxide biosynthetic process
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
interleukin-1 beta secretion
regulation of cytokine secretion
positive regulation of inflammatory response
defense response to Gram-negative bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
intestinal epithelial structure maintenance
positive regulation of macrophage cytokine production
necroptotic process
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to mechanical stimulus
apoptotic signaling pathway
positive regulation of NLRP3 inflammasome complex assembly

Function(s)

lipopolysaccharide binding
lipopolysaccharide receptor activity
receptor activity
transmembrane signaling receptor activity
protein binding