69389

• Gene Symbol: Syk
• Gene Name: spleen tyrosine kinase
• Gene Aliases: Sykb
• Chromosome Location: Chr.13: 52582329 - 52648792 on Build GRCm38
• UniGene ID: Mm.375031
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Syk
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001198977.1	NP_001185906.1	2	397
	NM_011518.2	NP_035648.2	2	401
GenBank mRNA	AK036736.1	-	2	325
	AK049207.1	-	3	495
	AK136363.1	-	2	400
	AK138741.1	-	2	332
	AK143564.1	-	2	430
	BB629720.1	-	2	323
	BC065121.1	-	2	333	30533300
	U25685.1	-	1	185
	U36776.1	-	2	404
	Z49877.1	-	2	662

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001174168, NM_001174167, NM_003177, NM_001135052, S80267, and others.

Panther Classification:

Molecular Function -

kinase modulator

Gene Ontology Categories:

Process(es)

activation of MAPK activity
angiogenesis
serotonin secretion
lymph vessel development
adaptive immune response
macrophage activation involved in immune response
neutrophil activation involved in immune response
leukocyte activation involved in immune response
immune system process
serotonin secretion by platelet
protein phosphorylation
leukocyte cell-cell adhesion
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
activation of JUN kinase activity
regulation of platelet activation
regulation of tumor necrosis factor-mediated signaling pathway
phosphorylation
cell migration
peptidyl-serine phosphorylation
peptidyl-tyrosine phosphorylation
leukotriene biosynthetic process
signal transduction by protein phosphorylation
cell differentiation
neutrophil chemotaxis
regulation of superoxide anion generation
positive regulation of cell adhesion mediated by integrin
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
defense response to bacterium
transcription factor import into nucleus
positive regulation of mast cell degranulation
regulation of neutrophil degranulation
beta selection
innate immune response
positive regulation of interleukin-3 biosynthetic process
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of bone resorption
positive regulation of alpha-beta T cell differentiation
positive regulation of alpha-beta T cell proliferation
protein autophosphorylation
blood vessel morphogenesis
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
regulation of phagocytosis
regulation of immune response
positive regulation of calcium-mediated signaling
B cell receptor signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
regulation of ERK1 and ERK2 cascade
cellular response to molecule of fungal origin
regulation of arachidonic acid secretion
regulation of platelet aggregation

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
receptor binding
integrin binding
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
protein domain specific binding