71408

• Gene Symbol: Tnf
• Gene Name: tumor necrosis factor
• Gene Aliases: DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa, Tnfsf1a
• Chromosome Location: Chr.17: 35199367 - 35202007 on Build GRCm38
• UniGene ID: Mm.1293
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tnf
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001278601.1	NP_001265530.1	3	547
	NM_013693.3	NP_038721.1	4	595
GenBank mRNA	AK153319.1	-	4	595
	AK153800.1	-	4	595
	AK154223.1	-	3	546
	AK155964.1	-	4	593
	BC117057.1	-	4	493	40126376
	BC137720.1	-	4	494	8860739
	M11731.1	-	4	571
	M13049.1	-	4	591
	X02611.1	-	4	584

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012675, XM_008772775, BC107671, AF269160, X66539, and others.

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPKKK activity
activation of MAPK activity
cell activation
positive regulation of cytokine production
regulation of protein phosphorylation
positive regulation of protein phosphorylation
negative regulation of L-glutamate transport
chronic inflammatory response to antigenic stimulus
negative regulation of cytokine secretion involved in immune response
positive regulation of chronic inflammatory response to antigenic stimulus
positive regulation of humoral immune response mediated by circulating immunoglobulin
glucose metabolic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
obsolete transformed cell apoptotic process
defense response
inflammatory response
immune response
humoral immune response
signal transduction
JNK cascade
multicellular organism development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
response to virus
organ morphogenesis
positive regulation of gene expression
negative regulation of gene expression
negative regulation of alkaline phosphatase activity
calcium-mediated signaling
extracellular matrix organization
osteoclast differentiation
sequestering of triglyceride
positive regulation of protein complex assembly
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
negative regulation of interleukin-6 production
positive regulation of chemokine production
positive regulation of interferon-gamma production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
receptor biosynthetic process
positive regulation of peptidyl-serine phosphorylation
tumor necrosis factor-mediated signaling pathway
positive regulation of heterotypic cell-cell adhesion
regulation of cell proliferation
positive regulation of NF-kappaB import into nucleus
defense response to bacterium
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of protein complex disassembly
positive regulation of protein complex disassembly
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAP kinase activity
protein kinase B signaling
positive regulation of JUN kinase activity
positive regulation of neuron apoptotic process
negative regulation of growth of symbiont in host
negative regulation of viral genome replication
positive regulation of chemokine biosynthetic process
cellular extravasation
positive regulation of interleukin-8 biosynthetic process
positive regulation of nitric oxide biosynthetic process
negative regulation of myoblast differentiation
negative regulation of osteoblast differentiation
regulation of osteoclast differentiation
positive regulation of osteoclast differentiation
positive regulation of action potential
positive regulation of cell adhesion
positive regulation of mitotic nuclear division
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of translational initiation by iron
negative regulation of glucose import
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of inflammatory response
positive regulation of phagocytosis
regulation of insulin secretion
positive regulation of synaptic transmission
defense response to Gram-positive bacterium
leukocyte migration
leukocyte tethering or rolling
detection of mechanical stimulus involved in sensory perception of pain
negative regulation of lipid catabolic process
regulation of immunoglobulin secretion
positive regulation of membrane protein ectodomain proteolysis
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein transport
response to glucocorticoid
positive regulation of NFAT protein import into nucleus
positive regulation of hair follicle development
positive regulation of protein kinase B signaling
positive regulation of vitamin D biosynthetic process
positive regulation of calcidiol 1-monooxygenase activity
epithelial cell proliferation involved in salivary gland morphogenesis
regulation of branching involved in salivary gland morphogenesis
negative regulation of branching involved in lung morphogenesis
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
cellular response to nicotine
cellular response to organic cyclic compound
positive regulation of podosome assembly
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
necroptotic signaling pathway
positive regulation of protein localization to cell surface
positive regulation of chemokine (C-X-C motif) ligand 2 production
regulation of reactive oxygen species metabolic process
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

protease binding
cytokine activity
tumor necrosis factor receptor binding
protein binding
identical protein binding
transcription regulatory region DNA binding