74372

• Gene Symbol: Sirt1
• Gene Name: sirtuin 1
• Gene Aliases: AA673258, SIR2L1, Sir2, Sir2a, Sir2alpha
• Chromosome Location: Chr.10: 63319005 - 63339061 on Build GRCm38
• UniGene ID: Mm.351459
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Sirt1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001159589.1	NP_001153061.1	3, 4	874
	NM_019812.2	NP_062786.1	4, 5	988
GenBank mRNA	AF214646.1	-	4, 5	973
	AK144203.1	-	3, 4	877
	AY377984.1	-	4, 5	973
	BC152314.1	-	4, 5	468	40111573

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_006256146.

Gene Ontology Categories:

Process(es)

single strand break repair
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
pyrimidine dimer repair by nucleotide-excision repair
DNA synthesis involved in DNA repair
angiogenesis
ovulation from ovarian follicle
cellular glucose homeostasis
positive regulation of protein phosphorylation
positive regulation of adaptive immune response
chromatin organization
establishment of chromatin silencing
maintenance of chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
rRNA processing
protein deacetylation
triglyceride mobilization
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
multicellular organism development
spermatogenesis
regulation of mitotic cell cycle
muscle organ development
positive regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
cellular response to starvation
positive regulation of heart rate
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
positive regulation of cholesterol efflux
regulation of glucose metabolic process
positive regulation of neuron projection development
positive regulation of skeletal muscle cell proliferation
positive regulation of macroautophagy
protein ubiquitination
histone deacetylation
peptidyl-lysine acetylation
cell differentiation
negative regulation of cell growth
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of prostaglandin biosynthetic process
protein destabilization
positive regulation of chromatin silencing
negative regulation of TOR signaling
regulation of endodeoxyribonuclease activity
negative regulation of NF-kappaB transcription factor activity
negative regulation of tumor necrosis factor production
response to insulin
circadian regulation of gene expression
regulation of protein import into nucleus, translocation
regulation of smooth muscle cell apoptotic process
peptidyl-lysine deacetylation
cellular triglyceride homeostasis
regulation of peroxisome proliferator activated receptor signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
negative regulation of phosphorylation
response to hydrogen peroxide
behavioral response to starvation
cholesterol homeostasis
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of MHC class II biosynthetic process
response to ethanol
negative regulation of fat cell differentiation
positive regulation of gluconeogenesis
positive regulation of DNA repair
negative regulation of transcription, DNA-templated
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of insulin receptor signaling pathway
rhythmic process
white fat cell differentiation
negative regulation of helicase activity
positive regulation of histone H3-K9 methylation
negative regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of growth hormone secretion
negative regulation of cell death
negative regulation of androgen receptor signaling pathway
histone H3-K9 modification
cellular response to hydrogen peroxide
regulation of bile acid biosynthetic process
UV-damage excision repair
histone H3 deacetylation
cellular response to tumor necrosis factor
negative regulation of histone H3-K14 acetylation
cellular response to hypoxia
cellular response to ionizing radiation
stress-induced premature senescence
negative regulation of neuron death
negative regulation of protein acetylation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of reactive oxygen species biosynthetic process
histone H3-K9 deacetylation
positive regulation of macrophage apoptotic process
negative regulation of fibroblast apoptotic process
negative regulation of cAMP-dependent protein kinase activity
positive regulation of cAMP-dependent protein kinase activity
regulation of energy homeostasis
positive regulation of thyroid-stimulating hormone secretion
negative regulation of histone H4-K16 acetylation
negative regulation of cellular response to testosterone stimulus
negative regulation of peptidyl-lysine acetylation
negative regulation of cellular senescence
positive regulation of cellular senescence

Function(s)

core promoter sequence-specific DNA binding
p53 binding
transcription corepressor activity
histone deacetylase activity
protein binding
protein C-terminus binding
transcription factor binding
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
NAD-dependent histone deacetylase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
deacetylase activity
enzyme binding
protein domain specific binding
protein deacetylase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
NAD-dependent protein deacetylase activity
histone binding
identical protein binding
HLH domain binding
protein kinase B binding
bHLH transcription factor binding
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
metal ion binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
N-acetylgalactosamine-6-phosphate deacetylase activity
mitogen-activated protein kinase binding
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
NAD+ binding
keratin filament binding