78962

• Gene Symbol: Lrrk2
• Gene Name: leucine-rich repeat kinase 2
• Gene Aliases: 4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46
• Chromosome Location: Chr.15: 91672821 - 91816124 on Build GRCm38
• UniGene ID: Mm.37558
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Lrrk2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_025730.3	NP_080006.3	43, 44	6446
GenBank mRNA	AK014886.1	-	4, 5	505
	AK014938.1	-	4, 5	518
	AY792512.1	-	43, 44	6389
	BC034074.1	-	9, 10	1329

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_198578, BC117180, AK122640, AK131537, AL832453, and others.
This siRNA also targets the following transcripts in Rat: NM_001191789, XM_008765689, XM_006242190.

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
protein phosphorylation
endocytosis
autophagy
response to oxidative stress
mitochondrion organization
Golgi organization
small GTPase mediated signal transduction
neuromuscular junction development
determination of adult lifespan
positive regulation of autophagy
regulation of protein kinase A signaling
negative regulation of protein processing
regulation of neuron maturation
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
olfactory bulb development
tangential migration from the subventricular zone to the olfactory bulb
cell differentiation
positive regulation of protein ubiquitination
negative regulation of protein binding
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of GTPase activity
cellular response to oxidative stress
cellular protein localization
intracellular signal transduction
regulation of kidney size
exploration behavior
locomotory exploration behavior
synaptic vesicle recycling
regulation of locomotion
regulation of membrane potential
positive regulation of programmed cell death
positive regulation of GTPase activity
GTP metabolic process
protein autophosphorylation
intracellular distribution of mitochondria
neuron projection morphogenesis
mitochondrion localization
regulation of mitochondrial depolarization
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of dendritic spine morphogenesis
neuron death
cellular response to manganese ion
reactive oxygen species metabolic process
regulation of neuron death
negative regulation of neuron death
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of protein autoubiquitination
regulation of neuroblast proliferation
regulation of synaptic vesicle transport
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
negative regulation of hydrogen peroxide-induced cell death
negative regulation of protein targeting to mitochondrion
cellular response to dopamine
regulation of branching morphogenesis of a nerve
regulation of synaptic vesicle exocytosis
negative regulation of peroxidase activity

Function(s)

SNARE binding
nucleotide binding
glycoprotein binding
actin binding
GTPase activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
GTPase activator activity
protein binding
ATP binding
GTP binding
tubulin binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Rho GTPase binding
syntaxin-1 binding
clathrin binding
GTP-dependent protein kinase activity
peroxidase inhibitor activity
identical protein binding
protein homodimerization activity
ion channel binding
protein kinase A binding