8052

Gene Symbol:

INS INS-IGF2

Gene Name:

insulin

INS-IGF2 readthrough

Gene Aliases:

IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10

INSIGF

Chromosome Location:

Chr.11: 2159779 - 2161209 on Build GRCh38

Chromosome Location:

Chr.11: 2129112 - 2161209 on Build GRCh38

UniGene ID:

Hs.272259

Hs.272259

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: INS
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000207.2	NP_000198.1	2	206
	NM_001185097.1	NP_001172026.1	2	232
	NM_001185098.1	NP_001172027.1	1	385
	NM_001291897.1	NP_001278826.1	2	266
GenBank mRNA	AY899304.1	-	2	202
	BC005255.1	-	2	206	3950204
	BM510347.1	-	2	227
	BM510748.1	-	2	210
	BP322143.1	-	1	385
	BT006808.1	-	1	147
	DQ778082.1	-	1	147
	JF909299.1	-	1	100
	JQ951950.1	-	2	191
	X70508.1	-	2	191

Gene Symbol: INS-IGF2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001042376.2	NP_001035835.1	2	206
	NR_003512.3		2	206
GenBank mRNA	DQ104204.1	-	2	206
	DQ104205.1	-	2	206

More Information

Panther Classification:

Molecular Function -

growth factor, intercellular signal molecule

Gene Ontology Categories:

Process(es)

MAPK cascade
negative regulation of acute inflammatory response
glucose metabolic process
regulation of transcription, DNA-templated
regulation of cellular amino acid metabolic process
ER to Golgi vesicle-mediated transport
acute-phase response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
regulation of transmembrane transporter activity
positive regulation of cell growth
positive regulation of cell migration
positive regulation of protein autophosphorylation
activation of protein kinase B activity
positive regulation of cellular protein metabolic process
negative regulation of protein oligomerization
regulation of protein localization
negative regulation of NAD(P)H oxidase activity
wound healing
negative regulation of protein catabolic process
glucose homeostasis
positive regulation of MAPK cascade
cellular protein metabolic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of proteolysis
negative regulation of vasodilation
positive regulation of vasodilation
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
positive regulation of lipid biosynthetic process
regulation of protein secretion
negative regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipid catabolic process
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of peptide hormone secretion
positive regulation of brown fat cell differentiation
positive regulation of protein localization to nucleus
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of feeding behavior

Function(s)

protease binding
insulin receptor binding
insulin-like growth factor receptor binding
hormone activity
protein binding
identical protein binding