8089

• Gene Symbol: NF1
• Gene Name: neurofibromin 1
• Gene Aliases: NFNS, VRNF, WSS
• Chromosome Location: Chr.17: 31094927 - 31377677 on Build GRCh38
• UniGene ID: Hs.113577
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NF1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000267.3	NP_000258.1	2	467
	NM_001042492.2	NP_001035957.1	2	467
	NM_001128147.2	NP_001121619.1	2	467
	XM_005257983.2	XP_005258040.1	2	417
	XM_005257984.2	XP_005258041.1	2	417
	XM_006721922.2	XP_006721985.1	2	417
	XM_006721924.2	XP_006721987.1	2	417
	XM_006721925.2	XP_006721988.1	2	417
	XM_006721926.3	XP_006721989.1	2	417
	XM_011524852.2	XP_011523154.1	2	417
	XM_011524857.2	XP_011523159.1	2	417
	XM_017024689.1	XP_016880178.1	2	417
	XM_017024690.1	XP_016880179.1	2	417
GenBank mRNA	AK289936.1	-	2	417
	BC144643.1	-	2	186
	D12625.1	-	2	467
	D42072.1	-	2	149
	DA299151.1	-	2	417
	DB094344.1	-	2	417
	M82814.1	-	2	295
	M89914.1	-	2	281

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012609, D45201.
This siRNA also targets the following transcripts in Mouse: NM_010897, AK085050, BB660074, L10370.

Panther Classification:

Molecular Function -

GTPase-activating protein

Gene Ontology Categories:

Process(es)

MAPK cascade
osteoblast differentiation
metanephros development
response to hypoxia
liver development
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
regulation of cell-matrix adhesion
negative regulation of cell-matrix adhesion
negative regulation of protein kinase activity
cell communication
Ras protein signal transduction
negative regulation of neuroblast proliferation
brain development
peripheral nervous system development
heart development
skeletal muscle tissue development
visual learning
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
Schwann cell development
phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
spinal cord development
amygdala development
forebrain astrocyte development
neural tube development
cerebral cortex development
myelination in peripheral nervous system
actin cytoskeleton organization
extracellular matrix organization
collagen fibril organization
adrenal gland development
negative regulation of cell migration
regulation of synaptic transmission, GABAergic
cellular response to heat
negative regulation of Rac protein signal transduction
wound healing
negative regulation of transcription factor import into nucleus
positive regulation of apoptotic process
regulation of GTPase activity
negative regulation of MAP kinase activity
negative regulation of MAPK cascade
pigmentation
positive regulation of neuron apoptotic process
regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
regulation of bone resorption
negative regulation of osteoclast differentiation
regulation of glial cell differentiation
positive regulation of adenylate cyclase activity
regulation of angiogenesis
negative regulation of Ras protein signal transduction
negative regulation of neurotransmitter secretion
negative regulation of fibroblast proliferation
regulation of long-term neuronal synaptic plasticity
sympathetic nervous system development
camera-type eye morphogenesis
negative regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
smooth muscle tissue development
artery morphogenesis
forebrain morphogenesis
cognition
gamma-aminobutyric acid secretion, neurotransmission
glutamate secretion, neurotransmission
observational learning
regulation of long-term synaptic potentiation
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

GTPase activator activity
protein binding
phosphatidylethanolamine binding
phosphatidylcholine binding