843

• Gene Symbol: PRKDC
• Gene Name: protein kinase, DNA-activated, catalytic polypeptide
• Gene Aliases: DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, IMD26, XRCC7, p350
• Chromosome Location: Chr.8: 47773108 - 47960183 on Build GRCh38
• UniGene ID: Hs.491682
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PRKDC
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001081640.1	NP_001075109.1	41, 42	5626
	NM_006904.6	NP_008835.5	41, 42	5626
GenBank mRNA	U34994.3	-	41, 42	5621
	U47077.5	-	41, 42	5626

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

somitogenesis
negative regulation of protein phosphorylation
B cell lineage commitment
pro-B cell differentiation
T cell lineage commitment
negative regulation of immunoglobulin production
positive regulation of immune system process
double-strand break repair
double-strand break repair via nonhomologous end joining
cellular protein modification process
brain development
heart development
cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
response to activity
telomere capping
peptidyl-serine phosphorylation
protein destabilization
positive regulation of type I interferon production
cellular response to insulin stimulus
T cell differentiation in thymus
immunoglobulin V(D)J recombination
T cell receptor V(D)J recombination
ectopic germ cell programmed cell death
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
rhythmic process
spleen development
thymus development
positive regulation of developmental growth
regulation of smooth muscle cell proliferation
signal transduction involved in mitotic G1 DNA damage checkpoint
double-strand break repair via alternative nonhomologous end joining
negative regulation of cellular senescence
negative regulation of response to gamma radiation

Function(s)

double-stranded DNA binding
protein kinase activity
protein serine/threonine kinase activity
DNA-dependent protein kinase activity
protein binding
ATP binding
transcription factor binding
enzyme binding
poly(A) RNA binding