8533

• Gene Symbol: XDH
• Gene Name: xanthine dehydrogenase
• Gene Aliases: XO, XOR
• Chromosome Location: Chr.2: 31334320 - 31414777 on Build GRCh38
• UniGene ID: Hs.250
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: XDH
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000379.3	NP_000370.2	18, 19	2061
	XM_011533095.2	XP_011531397.1	18, 19	2090
	XM_011533096.2	XP_011531398.1	18, 19	2092
GenBank mRNA	D11456.2	-	18, 19	2039
	U06117.1	-	18, 19	2045
	U39487.1	-	18, 19	2016

More Information

Panther Classification:

Molecular Function -

oxidoreductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

negative regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
purine nucleotide catabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
lactation
xanthine catabolic process
negative regulation of gene expression
negative regulation of endothelial cell differentiation
negative regulation of protein kinase B signaling
oxidation-reduction process
positive regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of reactive oxygen species metabolic process
negative regulation of vasculogenesis

Function(s)

xanthine dehydrogenase activity
xanthine oxidase activity
iron ion binding
electron carrier activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors
protein homodimerization activity
molybdopterin cofactor binding
flavin adenine dinucleotide binding
2 iron, 2 sulfur cluster binding