86015

• Gene Symbol: Tirap
• Gene Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
• Gene Aliases: AA407980, C130027E04Rik, Mal, Tlr4ap, Wyatt
• Chromosome Location: Chr.9: 35184391 - 35200291 on Build GRCm38
• UniGene ID: Mm.23987
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tirap
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001177845.1	NP_001171316.1	6	588
	NM_001177846.1	NP_001171317.1	6	570
	NM_001177847.1	NP_001171318.1	6	516
	NM_054096.2	NP_473437.2	6	580
GenBank mRNA	AF378130.1	-	6	489
	AF410784.1	-	5	412
	AK036431.1	-	6	509
	AK080135.1	-	6	589
	AK151117.1	-	6	518
	AK168494.1	-	6	508
	BC005584.1	-	3	246	3157913
	BY743490.1	-	6	516

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_001055833, XM_006242794.

Gene Ontology Categories:

Process(es)

immune system process
inflammatory response
signal transduction
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
activation of JUN kinase activity
response to bacterium
myeloid cell differentiation
positive regulation of B cell proliferation
response to lipopolysaccharide
regulation of interferon-beta production
regulation of interleukin-15 production
positive regulation of interleukin-12 production
positive regulation of interleukin-15 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of toll-like receptor 2 signaling pathway
positive regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
TIRAP-dependent toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of growth of symbiont in host
innate immune response
regulation of innate immune response
positive regulation of innate immune response
positive regulation of interleukin-6 biosynthetic process
positive regulation of JNK cascade
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
3'-UTR-mediated mRNA stabilization
cellular response to bacterial lipopeptide
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
positive regulation of protein homodimerization activity
positive regulation of chemokine (C-X-C motif) ligand 1 production
positive regulation of chemokine (C-X-C motif) ligand 2 production

Function(s)

protein kinase C binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
Toll-like receptor 4 binding
Toll-like receptor 2 binding
protein homodimerization activity
protein heterodimerization activity