8660

• Gene Symbol: IL6
• Gene Name: interleukin 6
• Gene Aliases: BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
• Chromosome Location: Chr.7: 22725889 - 22732002 on Build GRCh38
• UniGene ID: Hs.654458
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: IL6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000600.4	NP_000591.1	2	226
	XM_005249745.4	XP_005249802.1	1	366
	XM_011515390.2	XP_011513692.1	3	559
GenBank mRNA	A09363.1	-	2	191
	AK298013.1	-	1	330
	AK301141.1	-	2	221
	BC015511.1	-	2	154	3884652
	BT019748.1	-	2	105
	BT019749.1	-	2	105
	CR450296.1	-	2	105
	HY076725.1	-	2	227
	M14584.1	-	2	168
	M18403.1	-	2	167
	M29150.1	-	2	140
	M54894.1	-	2	155
	S56892.1	-	2	120
	X04403.1	-	1	12
	X04430.1	-	2	191
	X04602.1	-	2	138

More Information

Gene Ontology Categories:

Process(es)

neutrophil apoptotic process
response to yeast
hepatic immune response
neutrophil mediated immunity
monocyte chemotaxis
positive regulation of acute inflammatory response
positive regulation of leukocyte chemotaxis
negative regulation of protein kinase activity
acute-phase response
inflammatory response
humoral immune response
aging
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
response to heat
response to cold
regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of lipid storage
response to auditory stimulus
cell growth
cytokine-mediated signaling pathway
platelet activation
response to caffeine
endocrine pancreas development
neuron projection development
response to nutrient levels
response to peptidoglycan
positive regulation of chemokine production
positive regulation of interleukin-6 production
response to insulin
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein import into nucleus, translocation
cellular response to hepatocyte growth factor stimulus
positive regulation of T cell proliferation
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
defense response to protozoan
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to amino acid
positive regulation of MAPK cascade
negative regulation of chemokine biosynthetic process
regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of nitric oxide biosynthetic process
cell redox homeostasis
negative regulation of fat cell differentiation
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of gluconeogenesis
positive regulation of translation
positive regulation of DNA replication
regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
response to antibiotic
muscle cell cellular homeostasis
bone remodeling
negative regulation of hormone secretion
negative regulation of muscle organ development
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
negative regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
response to glucocorticoid
response to calcium ion
response to electrical stimulus
defense response to virus
positive regulation of protein kinase B signaling
positive regulation of transmission of nerve impulse
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
glucagon secretion
interleukin-6-mediated signaling pathway
cellular response to hydrogen peroxide
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to dexamethasone stimulus
positive regulation of cell proliferation in bone marrow
T-helper 17 cell lineage commitment
negative regulation of neuron death
positive regulation of STAT protein import into nucleus
positive regulation of type B pancreatic cell apoptotic process

Function(s)

cytokine activity
interleukin-6 receptor binding
protein binding
growth factor activity