87833

• Gene Symbol: Topors
• Gene Name: topoisomerase I binding, arginine/serine-rich
• Gene Aliases: AW105885, LUN, TP53BPL, p53BP3/LUN
• Chromosome Location: Chr.4: 40259606 - 40269841 on Build GRCm38
• UniGene ID: Mm.251548
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Topors
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_134097.3	NP_598858.2	3	2633
GenBank mRNA	AB072395.1	-	3	2590
	AB104865.1	-	3	2618
	BC019421.1	-	3	2591
	BC037141.1	-	3	2611
	BC040797.1	-	3	2621	3492178

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001195622, NM_005802, AF098300, AB045732, U82939, and others.

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
protein sumoylation
protein localization to nucleus
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
maintenance of protein location in nucleus
protein K48-linked ubiquitination

Function(s)

DNA binding
antigen binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
SUMO transferase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
DNA topoisomerase binding
metal ion binding
ubiquitin protein ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity