HSS103339

• Gene Symbol: ERCC2
• Gene Name: ERCC excision repair 2, TFIIH core complex helicase subunit
• Gene Aliases: COFS2, EM9, TFIIH, TTD, TTD1, XPD
• Chromosome Location: Chr.19: 45349837 - 45370647 on Build GRCh38
• UniGene ID: Hs.487294
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ERCC2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000400.3	NP_000391.1	12	1251
	NM_001130867.1	NP_001124339.1	11	1554
	XM_011526611.2	XP_011524913.1	11	1233
	XM_017026467.1	XP_016881956.1	11	1147
GenBank mRNA	AK130849.1	-	1	375
	BC008346.1	-	11	1351
	BC108255.1	-	12	1214	6044425
	BC110522.1	-	10	998	40034047
	BC110523.1	-	12	1232	40034048
	BT006883.1	-	11	1132
	X52221.1	-	11	1885

More Information

Panther Classification:

Molecular Function -

DNA helicase

Gene Ontology Categories:

Process(es)

nucleotide-excision repair, DNA duplex unwinding
response to hypoxia
in utero embryonic development
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
apoptotic process
response to oxidative stress
chromosome segregation
aging
cell proliferation
UV protection
post-embryonic development
viral process
spinal cord development
extracellular matrix organization
bone mineralization
central nervous system myelin formation
nucleotide-excision repair, DNA incision
multicellular organism growth
hair cell differentiation
embryonic cleavage
erythrocyte maturation
positive regulation of DNA binding
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hair follicle maturation
hematopoietic stem cell differentiation
global genome nucleotide-excision repair
regulation of mitotic cell cycle phase transition

Function(s)

DNA binding
ATP-dependent DNA helicase activity
protein kinase activity
protein binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
5'-3' DNA helicase activity
metal ion binding
protein N-terminus binding
4 iron, 4 sulfur cluster binding