HSS103776

• Gene Symbol: FMR1
• Gene Name: fragile X mental retardation 1
• Gene Aliases: FMRP, FRAXA, POF, POF1
• Chromosome Location: Chr.X: 147911951 - 147951127 on Build GRCh38
• UniGene ID: Hs.103183
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: FMR1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001185075.1	NP_001172004.1	4	464
	NM_001185076.1	NP_001172005.1	4	464
	NM_001185081.1	NP_001172010.1	4	464
	NM_001185082.1	NP_001172011.1	4	464
	NM_002024.5	NP_002015.1	4	464
	NR_033699.1		4	464
	NR_033700.1		4	464
GenBank mRNA	AB209188.1	-	1	689
	BC038998.1	-	4	429
	BC086957.1	-	4	494	30347992
	BQ213316.1	-	4	416
	KC774027.1	-	4	297
	KC774028.1	-	4	297
	KC774029.1	-	4	297
	KF856234.1	-	4	297
	KJ534836.1	-	4	235
	KJ534837.1	-	4	235
	KJ534838.1	-	4	235
	KM091457.1	-	4	297
	KM091458.1	-	4	297
	KM091459.1	-	4	297
	M67468.1	-	4	430
	S65791.1	-	4	454
	X69962.1	-	4	454

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_052804, XM_006229530, XM_006229531, XM_006229535, XM_008773597, and others.
This siRNA also targets the following transcripts in Mouse: NM_008031, NM_001290424, AK053701, AK080948, AK053211, and others.

Panther Classification:

Molecular Function -

translation factor

Gene Ontology Categories:

Process(es)

regulation of alternative mRNA splicing, via spliceosome
positive regulation of receptor internalization
mRNA processing
cellular response to DNA damage stimulus
glutamate receptor signaling pathway
RNA splicing
negative regulation of translation
gene silencing by RNA
positive regulation of histone phosphorylation
cellular response to UV
regulation of mRNA stability
modulation by host of viral RNA genome replication
positive regulation of translation
negative regulation of translational initiation
regulation of neurotransmitter secretion
mRNA transport
regulation of filopodium assembly
positive regulation of filopodium assembly
regulation of gene silencing by miRNA
regulation of dendritic spine development
positive regulation of dendritic spine development
cellular response to hydroxyurea
cellular response to virus
regulation of neuronal action potential
negative regulation of long term synaptic depression
positive regulation of intracellular transport of viral material
negative regulation of voltage-gated calcium channel activity
positive regulation of proteasomal protein catabolic process
positive regulation of mRNA binding
negative regulation of synaptic vesicle exocytosis
positive regulation of gene silencing by miRNA
negative regulation of cytoplasmic translation
positive regulation of response to DNA damage stimulus

Function(s)

G-quadruplex RNA binding
chromatin binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
protein binding
microtubule binding
poly(U) RNA binding
translation repressor activity
translation initiation factor binding
RNA strand annealing activity
poly(G) binding
methylated histone binding
siRNA binding
miRNA binding
RNA stem-loop binding
identical protein binding
protein homodimerization activity
ribosome binding
ion channel binding
poly(A) RNA binding
dynein binding
protein heterodimerization activity
mRNA 5'-UTR binding
sequence-specific mRNA binding