HSS105636

• Gene Symbol: JAK3
• Gene Name: Janus kinase 3
• Gene Aliases: JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
• Chromosome Location: Chr.19: 17824782 - 17848071 on Build GRCh38
• UniGene ID: Hs.515247
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: JAK3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000215.3	NP_000206.2	17	2421
	XM_005259896.3	XP_005259953.1	17	2460
	XM_011527990.1	XP_011526292.1	17	2460
GenBank mRNA	U09607.1	-	16	2416
	U31601.1	-	17	2416

More Information

Gene Ontology Categories:

Process(es)

MAPK cascade
adaptive immune response
negative regulation of dendritic cell cytokine production
protein phosphorylation
enzyme linked receptor protein signaling pathway
positive regulation of cytosolic calcium ion concentration
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
cell migration
peptidyl-tyrosine phosphorylation
B cell differentiation
negative regulation of interleukin-10 production
negative regulation of interleukin-12 production
intracellular signal transduction
interleukin-4-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
tyrosine phosphorylation of Stat5 protein
T cell homeostasis
positive regulation of GTPase activity
innate immune response
negative regulation of FasL biosynthetic process
negative regulation of T-helper 1 cell differentiation
positive regulation of immune response
negative regulation of T cell activation
positive regulation of calcium ion transport
JAK-STAT cascade involved in growth hormone signaling pathway
regulation of T cell apoptotic process
negative regulation of thymocyte apoptotic process
response to interleukin-2
response to interleukin-4
response to interleukin-15
response to interleukin-9

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
ATP binding
protein phosphatase binding