HSS140697

• Gene Symbol: LRRK2
• Gene Name: leucine rich repeat kinase 2
• Gene Aliases: AURA17, DARDARIN, PARK8, RIPK7, ROCO2
• Chromosome Location: Chr.12: 40224895 - 40369285 on Build GRCh38
• UniGene ID: Hs.187636
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: LRRK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_198578.3	NP_940980.3	42	6284
	XM_005268629.3	XP_005268686.1	42	6400
	XM_011537877.2	XP_011536179.1	42	6400
	XM_017018787.1	XP_016874276.1	21	3228
	XM_017018788.1	XP_016874277.1	17	2472
GenBank mRNA	AK122640.1	-	9	1192
	AK131537.1	-	17	2588
	AL832453.2	-	21	3457
	AY792511.1	-	42	6163
	BC117180.1	-	42	6221	40125731

More Information

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
protein phosphorylation
endocytosis
autophagy
response to oxidative stress
mitochondrion organization
Golgi organization
lysosome organization
small GTPase mediated signal transduction
neuromuscular junction development
determination of adult lifespan
cellular response to starvation
regulation of autophagy
positive regulation of autophagy
regulation of protein kinase A signaling
negative regulation of protein processing
regulation of neuron maturation
negative regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
calcium-mediated signaling
olfactory bulb development
tangential migration from the subventricular zone to the olfactory bulb
positive regulation of protein ubiquitination
negative regulation of protein binding
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of GTPase activity
cellular response to oxidative stress
cellular protein localization
intracellular signal transduction
regulation of kidney size
exploration behavior
locomotory exploration behavior
regulation of lysosomal lumen pH
regulation of locomotion
regulation of membrane potential
positive regulation of programmed cell death
positive regulation of MAP kinase activity
positive regulation of GTPase activity
GTP metabolic process
protein autophosphorylation
intracellular distribution of mitochondria
neuron projection morphogenesis
regulation of calcium-mediated signaling
mitochondrion localization
regulation of mitochondrial depolarization
regulation of synaptic transmission, glutamatergic
canonical Wnt signaling pathway
excitatory postsynaptic potential
regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of canonical Wnt signaling pathway
regulation of dendritic spine morphogenesis
protein localization to mitochondrion
neuron death
cellular response to manganese ion
reactive oxygen species metabolic process
regulation of mitochondrial fission
positive regulation of canonical Wnt signaling pathway
negative regulation of excitatory postsynaptic potential
regulation of neuron death
negative regulation of neuron death
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of protein autoubiquitination
regulation of neuroblast proliferation
regulation of synaptic vesicle transport
negative regulation of late endosome to lysosome transport
negative regulation of autophagosome assembly
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
negative regulation of hydrogen peroxide-induced cell death
negative regulation of protein targeting to mitochondrion
negative regulation of protein processing involved in protein targeting to mitochondrion
cellular response to dopamine
Wnt signalosome assembly
regulation of retrograde transport, endosome to Golgi
regulation of branching morphogenesis of a nerve
regulation of synaptic vesicle exocytosis
negative regulation of peroxidase activity

Function(s)

SNARE binding
glycoprotein binding
actin binding
GTPase activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
GTPase activator activity
protein binding
ATP binding
GTP binding
microtubule binding
tubulin binding
kinase activity
Rho GTPase binding
syntaxin-1 binding
receptor signaling complex scaffold activity
clathrin binding
GTP-dependent protein kinase activity
peroxidase inhibitor activity
co-receptor binding
identical protein binding
protein homodimerization activity
ion channel binding
protein kinase A binding
beta-catenin destruction complex binding