HSS150304

• Gene Symbol: SHANK3
• Gene Name: SH3 and multiple ankyrin repeat domains 3
• Gene Aliases: DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
• Chromosome Location: Chr.22: 50674642 - 50733212 on Build GRCh38
• UniGene ID: Hs.149035
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SHANK3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_033517.1	NP_277052.1	6	699
GenBank mRNA	AB569469.1	-	6	699

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_021676, AJ133120, AF133301.

Gene Ontology Categories:

Process(es)

MAPK cascade
synapse assembly
learning
memory
striatal medium spiny neuron differentiation
adult behavior
negative regulation of actin filament bundle assembly
social behavior
vocal learning
negative regulation of cell volume
positive regulation of long-term neuronal synaptic plasticity
brain morphogenesis
positive regulation of synapse structural plasticity
positive regulation of synaptic transmission, glutamatergic
dendritic spine morphogenesis
positive regulation of dendritic spine development
regulation of dendritic spine morphogenesis
vocalization behavior
postsynaptic density assembly
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
guanylate kinase-associated protein clustering
regulation of long-term synaptic potentiation
positive regulation of long-term synaptic potentiation
positive regulation of glutamate receptor signaling pathway
regulation of long term synaptic depression
positive regulation of excitatory postsynaptic potential
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Function(s)

actin binding
protein binding
protein C-terminus binding
zinc ion binding
SH3 domain binding
GKAP/Homer scaffold activity
ionotropic glutamate receptor binding
identical protein binding
scaffold protein binding