HSS150913

• Gene Symbol: TIRAP
• Gene Name: TIR domain containing adaptor protein
• Gene Aliases: BACTS1, Mal, MyD88-2, wyatt
• Chromosome Location: Chr.11: 126281268 - 126294933 on Build GRCh38
• UniGene ID: Hs.537126
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TIRAP
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001039661.1	NP_001034750.1	5	712
	NM_001318776.1	NP_001305705.1	4	559
	NM_001318777.1	NP_001305706.1	4	559
	NM_148910.2	NP_683708.1	5	728
	XM_005271399.3	XP_005271456.2	3	457
	XM_011542576.2	XP_011540878.1	3	457
	XM_017017161.1	XP_016872650.1	2	2080
	XM_017017162.1	XP_016872651.1	5	749
GenBank mRNA	AB446477.1	-	2	276
	AF378129.1	-	5	709
	AF406652.1	-	2	276
	AF410783.1	-	5	705
	AK124298.1	-	4	559
	AK313147.1	-	4	552
	AY576785.1	-	2	315
	AY576786.1	-	2	315
	AY576787.1	-	2	315
	BC032474.1	-	5	681	5216171

More Information

Gene Ontology Categories:

Process(es)

MyD88-dependent toll-like receptor signaling pathway
inflammatory response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
myeloid cell differentiation
positive regulation of B cell proliferation
response to lipopolysaccharide
regulation of interferon-beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-15 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of toll-like receptor 2 signaling pathway
positive regulation of toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
TIRAP-dependent toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of growth of symbiont in host
innate immune response
regulation of innate immune response
positive regulation of interleukin-6 biosynthetic process
positive regulation of JNK cascade
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
3'-UTR-mediated mRNA stabilization
cellular response to bacterial lipopeptide
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
positive regulation of protein homodimerization activity
positive regulation of chemokine (C-X-C motif) ligand 1 production
positive regulation of chemokine (C-X-C motif) ligand 2 production

Function(s)

protein kinase C binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
protein binding, bridging
Toll-like receptor 4 binding
Toll-like receptor 2 binding
protein homodimerization activity
protein heterodimerization activity