HSS153993

• Gene Symbol: PCSK9
• Gene Name: proprotein convertase subtilisin/kexin type 9
• Gene Aliases: FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
• Chromosome Location: Chr.1: 55039476 - 55064853 on Build GRCh38
• UniGene ID: Hs.18844
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PCSK9
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_174936.3	NP_777596.2	5, 6	1159
	NR_110451.1		3, 4	456
GenBank mRNA	AK075365.1	-	5, 6	1088
	AK122717.1	-	6, 7	844
	AK124635.1	-	2, 3	1618
	AK297473.1	-	3, 4	456
	EF692496.1	-	5, 6	797

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_199253, AY847775, BC133063.
This siRNA also targets the following transcripts in Mouse: NM_153565, BC038085, AK043077, AK149520, AY273821.

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

kidney development
liver development
negative regulation of receptor recycling
positive regulation of receptor internalization
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
cholesterol metabolic process
cellular response to starvation
regulation of receptor activity
negative regulation of low-density lipoprotein particle clearance
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity

Function(s)

serine-type endopeptidase activity
protein binding
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
poly(A) RNA binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding