HSS174249

• Gene Symbol: PARK7
• Gene Name: Parkinsonism associated deglycase
• Gene Aliases: DJ-1, DJ1, HEL-S-67p
• Chromosome Location: Chr.1: 7961654 - 7985282 on Build GRCh38
• UniGene ID: Hs.419640
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PARK7
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001123377.1	NP_001116849.1	4, 5	349
	NM_007262.4	NP_009193.2	4, 5	407
	XM_005263424.3	XP_005263481.1	4, 5	427
GenBank mRNA	AB073864.1	-	3, 4	244
	AF021819.1	-	4, 5	315
	AK312000.1	-	4, 5	302
	BP248330.1	-	4, 5	349
	D61380.2	-	3, 4	250
	EU794641.1	-	3, 4	250

More Information

Gene Ontology Categories:

Process(es)

negative regulation of protein phosphorylation
negative regulation of protein kinase activity
proteolysis
protein deglycosylation
autophagy
inflammatory response
mitochondrion organization
Ras protein signal transduction
single fertilization
adult locomotory behavior
detoxification of copper ion
positive regulation of gene expression
negative regulation of gene expression
enzyme active site formation via L-cysteine sulfinic acid
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
lactate biosynthetic process
protein repair
negative regulation of protein ubiquitination
negative regulation of protein binding
activation of protein kinase B activity
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of interleukin-8 production
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein sumoylation
cellular response to oxidative stress
cellular response to glyoxal
response to drug
hydrogen peroxide metabolic process
negative regulation of apoptotic process
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
regulation of TRAIL receptor biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
glycolate biosynthetic process
negative regulation of protein export from nucleus
regulation of inflammatory response
detoxification of mercury ion
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of ubiquitin-protein transferase activity
dopamine uptake involved in synaptic transmission
regulation of mitochondrial membrane potential
positive regulation of protein kinase B signaling
membrane depolarization
membrane hyperpolarization
negative regulation of cell death
regulation of androgen receptor signaling pathway
cellular response to hydrogen peroxide
positive regulation of protein homodimerization activity
cell-cell adhesion
cellular oxidant detoxification
positive regulation of protein localization to nucleus
negative regulation of neuron death
positive regulation of superoxide dismutase activity
negative regulation of protein acetylation
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
regulation of fibril organization
positive regulation of mitochondrial electron transport, NADH to ubiquinone
negative regulation of death-inducing signaling complex assembly
negative regulation of protein K48-linked deubiquitination
negative regulation of TRAIL-activated apoptotic signaling pathway
positive regulation of pyrroline-5-carboxylate reductase activity
positive regulation of tyrosine 3-monooxygenase activity
positive regulation of dopamine biosynthetic process
glyoxal catabolic process
positive regulation of L-dopa biosynthetic process
positive regulation of L-dopa decarboxylase activity
negative regulation of oxidative stress-induced cell death
negative regulation of hydrogen peroxide-induced cell death
negative regulation of hydrogen peroxide-induced neuron death
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
positive regulation of reactive oxygen species biosynthetic process
positive regulation of mitophagy
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
negative regulation of ubiquitin-specific protease activity
positive regulation of oxidative phosphorylation uncoupler activity
positive regulation of transcription regulatory region DNA binding
positive regulation of androgen receptor activity
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

core promoter binding
double-stranded DNA binding
single-stranded DNA binding
transcription coactivator activity
mRNA binding
receptor binding
copper ion binding
protein binding
transcription factor binding
peptidase activity
superoxide dismutase copper chaperone activity
oxidoreductase activity, acting on peroxide as acceptor
glyoxalase III activity
enzyme binding
kinase binding
cytokine binding
tyrosine 3-monooxygenase activator activity
L-dopa decarboxylase activator activity
identical protein binding
protein homodimerization activity
small protein activating enzyme binding
ubiquitin-like protein conjugating enzyme binding
mercury ion binding
androgen receptor binding
peroxiredoxin activity
repressing transcription factor binding
scaffold protein binding
cadherin binding involved in cell-cell adhesion
cupric ion binding
cuprous ion binding
ubiquitin-specific protease binding
glyoxalase (glycolic acid-forming) activity