HSS177026

Gene Symbol:

KLRK1 KLRC4-KLRK1

Gene Name:

killer cell lectin like receptor K1

KLRC4-KLRK1 readthrough

Gene Aliases:

CD314, D12S2489E, KLR, NKG2-D, NKG2D

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Chromosome Location:

Chr.12: 10372353 - 10390054 on Build GRCh38

Chromosome Location:

Chr.12: 10372353 - 10410146 on Build GRCh38

UniGene ID:

Hs.387787

Hs.387787

Species:

Human

Species Specific ID (Flybase ID):

-

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siRNA Details

Gene Symbol: KLRK1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_007360.3	NP_031386.2	7	686
GenBank mRNA	AF260135.1	-	6	509
	AF260136.1	-	6	509
	AK226161.1	-	5	1620
	AK292059.1	-	7	672
	BC039836.1	-	7	650	6067176

Gene Symbol: KLRC4-KLRK1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001199805.1	NP_001186734.1	12	1044
GenBank mRNA	AF439512.1	-	7	663
	AF461811.1	-	12	1053
	AK292020.1	-	12	1157
	X54870.1	-	9	847

More Information

Gene Ontology Categories:

Process(es)

stimulatory C-type lectin receptor signaling pathway
adaptive immune response
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
signal transduction
natural killer cell activation
cell differentiation
positive regulation of myeloid dendritic cell activation
T cell costimulation
positive regulation of interferon-gamma production
negative regulation of GTPase activity
positive regulation of apoptotic process
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of natural killer cell mediated cytotoxicity
regulation of immune response
defense response to Gram-positive bacterium
cellular response to lipopolysaccharide
negative regulation of natural killer cell chemotaxis

Function(s)

receptor activity
protein binding
kinase binding
carbohydrate binding
MHC class Ib receptor activity
MHC class I protein binding
protein homodimerization activity