HSS177678

• Gene Symbol: FYN
• Gene Name: FYN proto-oncogene, Src family tyrosine kinase
• Gene Aliases: SLK, SYN, p59-FYN
• Chromosome Location: Chr.6: 111660332 - 111873452 on Build GRCh38
• UniGene ID: Hs.390567
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: FYN
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002037.5	NP_002028.1	4	687
	NM_153047.3	NP_694592.1	1	91
	NM_153048.3	NP_694593.1	2	183
	XM_005266890.3	XP_005266947.1	4	268
	XM_005266892.3	XP_005266949.1	4	268
	XM_017010650.1	XP_016866139.1	3	425
	XM_017010651.1	XP_016866140.1	3	329
	XM_017010652.1	XP_016866141.1	2	339
	XM_017010653.1	XP_016866142.1	2	183
	XM_017010654.1	XP_016866143.1	2	164
	XM_017010655.1	XP_016866144.1	4	268
GenBank mRNA	AB451293.1	-	1	80
	AB451426.1	-	1	80
	AK056699.1	-	3	420
	BC032496.1	-	2	134	5219761
	CX781584.1	-	3	344
	CX872011.1	-	2	121
	DA815564.1	-	2	184
	DA922886.1	-	2	178
	M14333.1	-	4	659
	M14676.1	-	4	450
	S74774.1	-	1	80

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012755, XM_006256520, XM_006256522, XM_006256521, U35365.
This siRNA also targets the following transcripts in Mouse: NM_008054, NM_001122892, NM_001122893, AK171646, BC032149, and others.

Panther Classification:

Molecular Function -

kinase modulator

Gene Ontology Categories:

Process(es)

MAPK cascade
neuron migration
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
protein phosphorylation
calcium ion transport
transmembrane receptor protein tyrosine kinase signaling pathway
axon guidance
central nervous system development
blood coagulation
learning
feeding behavior
regulation of cell shape
negative regulation of gene expression
positive regulation of neuron projection development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
platelet activation
forebrain development
T cell costimulation
negative regulation of protein ubiquitination
intracellular signal transduction
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
T cell activation
regulation of cell proliferation
negative regulation of protein catabolic process
response to drug
positive regulation of tyrosine phosphorylation of Stat5 protein
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
innate immune response
response to ethanol
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
phosphatidylinositol-mediated signaling
dendrite morphogenesis
regulation of defense response to virus by virus
activated T cell proliferation
T cell receptor signaling pathway
leukocyte migration
detection of mechanical stimulus involved in sensory perception of pain
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

G-protein coupled receptor binding
glycoprotein binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
tubulin binding
T cell receptor binding
CD4 receptor binding
CD8 receptor binding
phosphatidylinositol 3-kinase binding
ion channel binding
metal ion binding
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
peptide hormone receptor binding
growth factor receptor binding