HSS180911

• Gene Symbol: LRP6
• Gene Name: LDL receptor related protein 6
• Gene Aliases: ADCAD2, STHAG7
• Chromosome Location: Chr.12: 12116025 - 12267021 on Build GRCh38
• UniGene ID: Hs.584775
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: LRP6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002336.2	NP_002327.2	6, 7	1512
	XM_006719078.3	XP_006719141.1	6, 7	1656
	XM_011520671.2	XP_011518973.1	5, 6	1262
	XM_017019304.1	XP_016874793.1	4, 5	1330
GenBank mRNA	AB209683.1	-	5, 6	964
	AF074264.1	-	6, 7	1447
	BC117136.1	-	6, 7	1404	40125687
	BC126405.1	-	6, 7	1404	8992121
	BC143725.1	-	6, 7	1404	9052239

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_008514, AF074265, BC060704.

Panther Classification:

Molecular Function -

apolipoprotein

Gene Ontology Categories:

Process(es)

neural tube closure
negative regulation of protein phosphorylation
pericardium morphogenesis
negative regulation of protein kinase activity
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
embryonic pattern specification
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
single organismal cell-cell adhesion
cerebellum morphogenesis
thalamus development
cerebral cortex development
midbrain-hindbrain boundary development
negative regulation of smooth muscle cell apoptotic process
external genitalia morphogenesis
odontogenesis of dentin-containing tooth
response to peptide hormone
Wnt signaling pathway involved in dorsal/ventral axis specification
canonical Wnt signaling pathway involved in neural crest cell differentiation
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
convergent extension
embryonic retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
face morphogenesis
trachea cartilage morphogenesis
cellular response to cholesterol
dopaminergic neuron differentiation
negative regulation of protein serine/threonine kinase activity
protein localization to plasma membrane
primitive streak formation
negative regulation of canonical Wnt signaling pathway
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Wnt signaling pathway involved in somitogenesis
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
toxin transport
beta-catenin destruction complex disassembly
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

Function(s)

low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
apolipoprotein binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway