HSS180982

• Gene Symbol: ARRB2
• Gene Name: arrestin beta 2
• Gene Aliases: ARB2, ARR2, BARR2
• Chromosome Location: Chr.17: 4710494 - 4721500 on Build GRCh38
• UniGene ID: Hs.435811
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ARRB2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001257328.1	NP_001244257.1	1, 2	251
	NM_001257329.1	NP_001244258.1	1, 2	251
	NM_001257330.1	NP_001244259.1	1, 2	251
	NM_001257331.1	NP_001244260.1	1, 2	251
	NM_004313.3	NP_004304.1	1, 2	251
	NM_199004.1	NP_945355.1	1, 2	251
GenBank mRNA	AF106941.1	-	1, 2	76
	AK097542.1	-	1, 2	111
	AK290951.1	-	1, 2	52
	BC007427.2	-	1, 2	85	3028154
	BC039066.1	-		14
	BC067368.1	-	1, 2	79	5748319
	BC095450.1	-	1, 2	49
	BG723452.1	-	1, 2	261
	CR450310.1	-	1, 2	23
	DQ664180.1	-	1, 2	23
	EU883572.1	-	1, 2	23
	Z11501.1	-	1, 2	23

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012911, BC087578, M91590.
This siRNA also targets the following transcripts in Mouse: NM_145429, NM_001271360, NM_001271358, NM_001271359, AK150389, and others.

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

G-protein coupled receptor internalization
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
positive regulation of receptor internalization
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
dopamine receptor signaling pathway
brain development
adult walking behavior
protein transport
protein ubiquitination
platelet activation
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
receptor internalization
negative regulation of NF-kappaB transcription factor activity
positive regulation of synaptic transmission, dopaminergic
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of peptidyl-serine phosphorylation
negative regulation of toll-like receptor signaling pathway
negative regulation of GTPase activity
negative regulation of smooth muscle cell apoptotic process
follicle-stimulating hormone signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of peptidyl-tyrosine phosphorylation
detection of temperature stimulus involved in sensory perception of pain
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
positive regulation of calcium ion transport
Wnt signaling pathway, planar cell polarity pathway
cell chemotaxis
regulation of androgen receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
negative regulation of release of cytochrome c from mitochondria
chemical synaptic transmission, postsynaptic
positive regulation of DNA biosynthetic process

Function(s)

G-protein coupled receptor binding
receptor binding
protein binding
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
alpha-1A adrenergic receptor binding
alpha-1B adrenergic receptor binding
angiotensin receptor binding
type 1 angiotensin receptor binding
D1 dopamine receptor binding
follicle-stimulating hormone receptor binding
type 2A serotonin receptor binding
platelet activating factor receptor binding
protein complex binding
protein complex scaffold
protein kinase B binding
mitogen-activated protein kinase binding
14-3-3 protein binding