HSS183391

• Gene Symbol: MAP2K5
• Gene Name: mitogen-activated protein kinase kinase 5
• Gene Aliases: HsT17454, MAPKK5, MEK5, PRKMK5
• Chromosome Location: Chr.15: 67542606 - 67807117 on Build GRCh38
• UniGene ID: Hs.114198
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MAP2K5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001206804.1	NP_001193733.1	4	339
	NM_002757.3	NP_002748.1	4	923
	NM_145160.2	NP_660143.1	4	923
	XM_011521787.2	XP_011520089.1	4	1000
	XM_011521788.2	XP_011520090.1	4	1000
	XM_017022414.1	XP_016877903.1	4	1000
GenBank mRNA	AK293459.1	-	4	339
	AK315435.1	-	4	470
	BC008838.2	-	4	580	4100679
	BT006780.1	-	4	270
	CR542229.1	-	4	270
	U71087.1	-	4	331
	U71088.2	-	4	275

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_017246, NM_001033987, XM_008766221, XM_006243229, BC078860, and others.
This siRNA also targets the following transcripts in Mouse: NM_011840, AK020716, BC028260, AK166137, BC013697, and others.

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
signal transduction
heart development
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
negative regulation of NF-kappaB transcription factor activity
negative regulation of heterotypic cell-cell adhesion
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
positive regulation of protein metabolic process
negative regulation of response to cytokine stimulus
ERK5 cascade
cellular response to growth factor stimulus
cellular response to laminar fluid shear stress
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of chemokine (C-X-C motif) ligand 2 production
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

protein kinase activity
receptor signaling protein serine/threonine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
metal ion binding