HSS186391

• Gene Symbol: TP53
• Gene Name: tumor protein p53
• Gene Aliases: BCC7, LFS1, P53, TRP53
• Chromosome Location: Chr.17: 7668402 - 7687550 on Build GRCh38
• UniGene ID: Hs.437460
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TP53
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000546.5	NP_000537.3	6, 7	876
	NM_001126112.2	NP_001119584.1	6, 7	873
	NM_001126113.2	NP_001119585.1	6, 7	876
	NM_001126114.2	NP_001119586.1	6, 7	876
	NM_001126115.1	NP_001119587.1	2, 3	556
	NM_001126116.1	NP_001119588.1	2, 3	556
	NM_001126117.1	NP_001119589.1	2, 3	556
	NM_001126118.1	NP_001119590.1	5, 6	993
	NM_001276695.1	NP_001263624.1	6, 7	876
	NM_001276696.1	NP_001263625.1	6, 7	876
	NM_001276697.1	NP_001263626.1	2, 3	556
	NM_001276698.1	NP_001263627.1	2, 3	556
	NM_001276699.1	NP_001263628.1	2, 3	556
	NM_001276760.1	NP_001263689.1	6, 7	876
	NM_001276761.1	NP_001263690.1	6, 7	873
GenBank mRNA	AB082923.1	-	6, 7	737
	AF307851.1	-	6, 7	809
	AK225838.1	-	6, 7	814
	AK297462.1	-	7, 8	741
	AK297927.1	-	7, 8	786
	AK312568.1	-	6, 7	818
	AM076970.1	-	5, 6	641
	AM076971.1	-	5, 6	674
	AM076972.1	-	5, 6	674
	AY429684.1	-	5, 6	674
	BC003596.1	-	6, 7	794	3544714
	BT019622.1	-	5, 6	674
	DQ186648.1	-	6, 7	806
	DQ186649.1	-	6, 7	806
	DQ186650.1	-	2, 3	552
	DQ186651.1	-	2, 3	552
	DQ186652.1	-	2, 3	552
	DQ191317.1	-	6, 7	863
	DQ263704.1	-	5, 6	674
	DQ286964.1	-	6, 7	808
	DQ648884.1	-	5, 6	474
	DQ648885.1	-	3, 4	350
	EF101867.1	-	5, 6	641
	EF101868.1	-	5, 6	674
	EF101869.1	-	5, 6	674
	FJ207420.1	-	6, 7	809
	JN214348.1	-	5, 6	719
	JN601513.1	-	5, 6	674
	JN601514.1	-	5, 6	674
	JN601515.1	-	5, 6	674
	JN601516.1	-	6, 7	648
	JN900492.1	-	5, 6	982
	JQ026207.1	-	5, 6	664
	JQ026208.1	-	5, 6	669
	JQ026210.1	-	5, 6	674
	JQ694049.1	-	5, 6	697
	JQ694050.1	-	5, 6	697
	JQ694051.1	-	5, 6	697
	KC820708.1	-	2, 3	169
	KC820709.1	-	2, 3	169
	KC820710.1	-	2, 3	169
	KC820711.1	-	2, 3	169
	KC820712.1	-	2, 3	169
	KC820713.1	-	2, 3	169
	KC820714.1	-	2, 3	169
	KC820715.1	-	2, 3	169
	KC820716.1	-	2, 3	169
	KC820717.1	-	2, 3	169
	KC820718.1	-	2, 3	169
	KC820719.1	-	2, 3	169
	KC820720.1	-	2, 3	169
	KC820721.1	-	2, 3	169
	KC820722.1	-	2, 3	169
	KC820723.1	-	2, 3	169
	KC820724.1	-	2, 3	169
	KC820725.1	-	2, 3	169
	KC820726.1	-	2, 3	169
	KC820727.1	-	2, 3	169
	KC820728.1	-	2, 3	169
	KC820729.1	-	2, 3	169
	KC820730.1	-	2, 3	169
	KC820731.1	-	2, 3	169
	KC820732.1	-	2, 3	169
	KC820733.1	-	2, 3	169
KC820734.1	-	2, 3	169
KC820735.1	-	2, 3	169
KC820736.1	-	2, 3	169
KC820737.1	-	2, 3	169
KC820738.1	-	2, 3	169
KC820739.1	-	2, 3	169
KC820740.1	-	2, 3	169
KC820741.1	-	2, 3	169
KC820742.1	-	2, 3	169
KC820743.1	-	2, 3	169
KC820744.1	-	2, 3	169
KC820745.1	-	2, 3	169
KC820746.1	-	2, 3	169
KC820747.1	-	2, 3	169
KC820748.1	-	2, 3	169
KC820749.1	-	2, 3	169
KC820750.1	-	2, 3	169
KC820751.1	-	2, 3	169
KC820752.1	-	2, 3	169
KC820753.1	-	2, 3	169
KC820754.1	-	2, 3	169
KC820755.1	-	2, 3	169
KC820756.1	-	2, 3	169
KC820757.1	-	2, 3	169
KC820758.1	-	2, 3	169
KC820760.1	-	2, 3	169
KC820761.1	-	2, 3	169
KC820762.1	-	2, 3	169
KC820763.1	-	2, 3	169
KC820764.1	-	2, 3	169
KC820765.1	-	2, 3	169
KC820766.1	-	2, 3	169
KC820767.1	-	2, 3	169
KC820768.1	-	2, 3	169
KC820769.1	-	2, 3	169
KC820770.1	-	2, 3	169
KC820771.1	-	2, 3	169
KC820772.1	-	2, 3	169
KC820773.1	-	2, 3	169
KC820774.1	-	2, 3	169
KC820775.1	-	2, 3	169
KC820776.1	-	2, 3	169
KC820777.1	-	2, 3	169
KC820778.1	-	2, 3	169
KC820779.1	-	2, 3	169
KC820780.1	-	2, 3	169
KC820781.1	-	2, 3	169
KC820782.1	-	2, 3	169
KC820783.1	-	2, 3	169
KC820784.1	-	2, 3	169
KC820785.1	-	2, 3	169
KC820786.1	-	2, 3	169
M14694.1	-	6, 7	799
M14695.1	-	6, 7	795
X01405.1	-	3, 4	375
X02469.1	-	6, 7	809
X60010.1	-	5, 6	673
X60011.1	-	5, 6	674
X60012.1	-	5, 6	674
X60013.1	-	5, 6	674
X60014.1	-	5, 6	674
X60015.1	-	5, 6	674
X60016.1	-	5, 6	674
X60017.1	-	5, 6	674
X60018.1	-	5, 6	674
X60019.1	-	5, 6	674
X60020.1	-	5, 6	674

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_003749209.

Panther Classification:

Molecular Function -

P53-like transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA strand renaturation
base-excision repair
nucleotide-excision repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein complex assembly
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
ER overload response
cell cycle arrest
Ras protein signal transduction
multicellular organism development
cell aging
protein localization
cell proliferation
negative regulation of cell proliferation
determination of adult lifespan
response to X-ray
response to gamma radiation
positive regulation of gene expression
viral process
protein sumoylation
cell differentiation
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
positive regulation of histone deacetylation
chromatin assembly
mitotic G1 DNA damage checkpoint
positive regulation of protein oligomerization
cellular response to UV
cellular response to drug
cellular response to glucose starvation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of neuron apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
positive regulation of protein export from nucleus
regulation of mitochondrial membrane permeability
negative regulation of fibroblast proliferation
circadian behavior
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of helicase activity
protein tetramerization
negative regulation of telomerase activity
positive regulation of thymocyte apoptotic process
positive regulation of cell cycle arrest
cellular response to hypoxia
cellular response to ionizing radiation
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of release of cytochrome c from mitochondria
replicative senescence
oxidative stress-induced premature senescence
intrinsic apoptotic signaling pathway
oligodendrocyte apoptotic process
positive regulation of execution phase of apoptosis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
regulation of cell cycle G2/M phase transition
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of reactive oxygen species metabolic process
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protease binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
copper ion binding
protein binding
ATP binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
protein phosphatase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
protein heterodimerization activity
protein N-terminus binding
chaperone binding
protein phosphatase 2A binding