MSS201961

• Gene Symbol: Alox8
• Gene Name: arachidonate 8-lipoxygenase
• Gene Aliases: 15-LOX-2, 15-LOX-B, 8-LOX, 8S-LOX, Alox15b
• Chromosome Location: Chr.11: 69183885 - 69197843 on Build GRCm38
• UniGene ID: Mm.289672
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Alox8
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_009661.4	NP_033791.1	11, 12	1617
GenBank mRNA	AK028724.1	-	11, 12	1613
	AK158553.1	-	9, 10	1491
	BC015253.1	-	11, 12	1617	4221815
	U93277.1	-	11, 12	1583
	Y14696.1	-	11, 12	1596

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_153301, AF415240.

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Process(es)

lipid metabolic process
negative regulation of cell proliferation
positive regulation of macrophage derived foam cell differentiation
arachidonic acid metabolic process
lipoxygenase pathway
positive regulation of peroxisome proliferator activated receptor signaling pathway
linoleic acid metabolic process
positive regulation of keratinocyte differentiation
negative regulation of cell cycle
negative regulation of growth
hepoxilin biosynthetic process
oxidation-reduction process
positive regulation of chemokine secretion

Function(s)

iron ion binding
calcium ion binding
lipid binding
linoleate 13S-lipoxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
2,3-dihydroxy DDT 1,2-dioxygenase activity
phenanthrene dioxygenase activity
2,2',3-trihydroxybiphenyl dioxygenase activity
1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
protocatechuate 3,4-dioxygenase type II activity
2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
carbazole 1,9a-dioxygenase activity
dihydroxydibenzothiophene dioxygenase activity
1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
styrene dioxygenase activity
3,4-dihydroxyphenanthrene dioxygenase activity
hydroquinone 1,2-dioxygenase activity
p-cumate 2,3-dioxygenase activity
2,3-dihydroxy-p-cumate dioxygenase activity
3,5-dichlorocatechol 1,2-dioxygenase activity
2-aminophenol 1,6-dioxygenase activity
2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
chlorocatechol 1,2-dioxygenase activity
catechol dioxygenase activity
dihydroxyfluorene dioxygenase activity
5-aminosalicylate dioxygenase activity
3-hydroxy-2-naphthoate 2,3-dioxygenase activity
benzo(a)pyrene 11,12-dioxygenase activity
benzo(a)pyrene 4,5-dioxygenase activity
4,5-dihydroxybenzo(a)pyrene dioxygenase activity
benzo(a)pyrene 9,10-dioxygenase activity
9,10-dihydroxybenzo(a)pyrene dioxygenase activity
benzo(a)pyrene 7,8-dioxygenase activity
7,8-dihydroxy benzo(a)pyrene dioxygenase activity
1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
2-mercaptobenzothiazole dioxygenase activity
pyridine-3,4-diol dioxygenase activity
pyrene dioxygenase activity
4,5-dihydroxypyrene dioxygenase activity
phenanthrene-4-carboxylate dioxygenase activity
tetrachlorobenzene dioxygenase activity
4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
2,3-dihydroxydiphenyl ether dioxygenase activity
diphenyl ether 1,2-dioxygenase activity
arachidonate 8(S)-lipoxygenase activity
metal ion binding
4-hydroxycatechol 1,2-dioxygenase activity
arachidonate 8(R)-lipoxygenase activity
arachidonate 15-lipoxygenase activity
dioxygenase activity