MSS202508

• Gene Symbol: Cacna1a
• Gene Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
• Gene Aliases: APCA, BI, Caca1a, Cacnl1a4, Cav2.1, Ccha1a, EA2, FHM, HPCA, MHP, MHP1, SCA6, alpha1A, la, nmf352, rkr, tg
• Chromosome Location: Chr.8: 84338633 - 84640249 on Build GRCm38
• UniGene ID: Mm.334658
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Cacna1a
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001252059.1	NP_001238988.1	23, 24	3989
	NM_001252060.1	NP_001238989.1	24, 25	4130
	NM_001252061.1	NP_001238990.1	24, 25	4130
	NM_007578.3	NP_031604.3	24, 25	4130
GenBank mRNA	AB066608.1	-	24, 25	3903
	AB066609.1	-	24, 25	3903
	AK147277.1	-	23, 24	3977
	AK147288.1	-	24, 25	4130
	AK147498.1	-	23, 24	3977
	AK147697.1	-	23, 24	3977
	AY714490.1	-	24, 25	3903
	U76716.1	-	24, 25	3705

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_000068, NM_001174080, NM_001127222, NM_023035, NM_001127221, and others.
This siRNA also targets the following transcripts in Rat: NM_012918, XM_008772361, XM_008772357, XM_008772356, XM_008772351, and others.

Panther Classification:

Molecular Function -

voltage-gated ion channel

Gene Ontology Categories:

Process(es)

sulfur amino acid metabolic process
glucose metabolic process
transport
ion transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuron-neuron synaptic transmission
neuromuscular synaptic transmission
synapse assembly
adult walking behavior
cell death
gamma-aminobutyric acid secretion
regulation of acetylcholine secretion, neurotransmission
cell growth
calcium ion regulated exocytosis
regulation of calcium ion-dependent exocytosis
transmission of nerve impulse
sensory perception of pain
spinal cord motor neuron differentiation
cerebellum maturation
cerebellar molecular layer development
cerebellar Purkinje cell layer development
cerebellar Purkinje cell differentiation
vestibular nucleus development
central nervous system neuron differentiation
cellular chloride ion homeostasis
negative regulation of hormone biosynthetic process
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
neurotransmitter metabolic process
regulation of membrane potential
thyroid hormone metabolic process
hormone metabolic process
receptor clustering
negative regulation of neuron apoptotic process
response to pain
behavioral response to pain
calcium ion-regulated exocytosis of neurotransmitter
dendrite morphogenesis
regulation of axonogenesis
neurological system process
musculoskeletal movement, spinal reflex action
neuromuscular process controlling balance
neuromuscular process
membrane depolarization
synaptic transmission, GABAergic
transmembrane transport
rhythmic synaptic transmission
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential

Function(s)

DNA binding
ion channel activity
voltage-gated ion channel activity
voltage-gated calcium channel activity
calcium channel activity
protein binding
calmodulin binding
high voltage-gated calcium channel activity
syntaxin binding
metal ion binding