MSS205076

• Gene Symbol: Hdac6
• Gene Name: histone deacetylase 6
• Gene Aliases: Hd6, Hdac5, Sfc6, mHDA2
• Chromosome Location: Chr.X: 7930120 - 7947889 on Build GRCm38
• UniGene ID: Mm.29854
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Hdac6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001130416.1	NP_001123888.1	27, 28	3531
	NM_010413.3	NP_034543.3	27, 28	3606
GenBank mRNA	AF006603.2	-	26, 27	3291
	AK148092.1	-	27, 28	3452
	AK154099.1	-	27, 28	3470
	AK155545.1	-	25, 26	4504
	AK155546.1	-	27, 28	3473
	BC033428.1	-	17, 18	2382
	BC041105.1	-	27, 28	3463	5352032
	BM250542.2	-	2, 3	533

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_006256756, XM_228753, XM_003752010, XM_006256759, XM_006256755, and others.

Gene Ontology Categories:

Process(es)

protein polyubiquitination
transcription, DNA-templated
regulation of transcription, DNA-templated
protein deacetylation
ubiquitin-dependent protein catabolic process
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
negative regulation of microtubule depolymerization
response to toxic substance
positive regulation of signal transduction
response to organic substance
regulation of receptor activity
positive regulation of epithelial cell migration
positive regulation of receptor biosynthetic process
macroautophagy
chromatin modification
histone deacetylation
lysosome localization
peptidyl-lysine deacetylation
cellular response to topologically incorrect protein
regulation of gene expression, epigenetic
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein complex disassembly
negative regulation of protein complex disassembly
regulation of fat cell differentiation
negative regulation of proteolysis
mitochondrion localization
response to misfolded protein
regulation of establishment of protein localization
cellular response to hydrogen peroxide
aggresome assembly
polyubiquitinated misfolded protein transport
Hsp90 deacetylation
response to growth factor
cellular response to misfolded protein
positive regulation of chaperone-mediated protein complex assembly
tubulin deacetylation
mitophagy in response to mitochondrial depolarization
positive regulation of hydrogen peroxide-mediated programmed cell death

Function(s)

core promoter binding
actin binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
hydrolase activity
histone deacetylase activity (H3-K14 specific)
polyubiquitin binding
ubiquitin protein ligase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
ubiquitin binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
dynein complex binding
NAD-dependent histone deacetylase activity (H3-K18 specific)