MSS205125

• Gene Symbol: Hif1a
• Gene Name: hypoxia inducible factor 1, alpha subunit
• Gene Aliases: AA959795, HIF1alpha, MOP1, bHLHe78
• Chromosome Location: Chr.12: 73901329 - 73947530 on Build GRCm38
• UniGene ID: Mm.3879
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Hif1a
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010431.2	NP_034561.2	15	2916
GenBank mRNA	AF003695.1	-	15	2750
	AK033471.1	-	4	516
	AK034087.1	-	15	2882
	AK076395.1	-	13	2204
	AK150367.1	-	15	2783
	BC026139.1	-	15	2768	4019056
	X95580.1	-	15	2540

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001243084, NM_001530, NM_181054, U22431, BX648795, and others.
This siRNA also targets the following transcripts in Rat: NM_024359, XM_006240197, XM_006240196, XM_006240199, XM_008764695, and others.

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

angiogenesis
blood vessel development
response to hypoxia
neural crest cell migration
epithelial to mesenchymal transition
embryonic placenta development
B-1 B cell homeostasis
vasculature development
heart looping
positive regulation of neuroblast proliferation
connective tissue replacement involved in inflammatory response wound healing
outflow tract morphogenesis
cardiac ventricle morphogenesis
lactate metabolic process
regulation of glycolytic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular iron ion homeostasis
signal transduction
lactation
positive regulation of cell proliferation
visual learning
regulation of gene expression
positive regulation of autophagy
vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of receptor biosynthetic process
response to muscle activity
axonal transport of mitochondrion
neural fold elevation formation
cerebral cortex development
cell differentiation
negative regulation of bone mineralization
positive regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of TOR signaling
oxygen homeostasis
regulation of transforming growth factor beta2 production
collagen metabolic process
negative regulation of transcription elongation from RNA polymerase II promoter
embryonic hemopoiesis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
hemoglobin biosynthetic process
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
negative regulation of vasoconstriction
negative regulation of growth
positive regulation of transcription from RNA polymerase II promoter
muscle cell cellular homeostasis
positive regulation of hormone biosynthetic process
blood vessel morphogenesis
digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
regulation of catalytic activity
cartilage development
elastin metabolic process
intestinal epithelial cell maturation
response to fungicide
epithelial cell differentiation involved in mammary gland alveolus development
retina vasculature development in camera-type eye
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of thymocyte apoptotic process
negative regulation of thymocyte apoptotic process
cellular response to hypoxia
dopaminergic neuron differentiation
hypoxia-inducible factor-1alpha signaling pathway
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of mitophagy
regulation of aerobic respiration
negative regulation of reactive oxygen species metabolic process
negative regulation of mesenchymal cell apoptotic process

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, transcription factor binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
signal transducer activity
protein binding
transcription factor binding
enzyme binding
protein kinase binding
ubiquitin protein ligase binding
protein complex binding
histone acetyltransferase binding
nuclear hormone receptor binding
histone deacetylase binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
Hsp90 protein binding