MSS205148

• Gene Symbol: Hmgcr
• Gene Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
• Gene Aliases: HMG-CoAR, Red
• Chromosome Location: Chr.13: 96648962 - 96670936 on Build GRCm38
• UniGene ID: Mm.316652
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Hmgcr
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008255.2	NP_032281.2	19	2616
GenBank mRNA	AK079302.1	-	7	815
	AK159899.1	-	18	2504
	AK198607.1	-	3	231
	BC059873.1	-	10	1297
	BC085083.1	-	19	2528	5320486
	M62766.1	-	4	478

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_000859, NM_001130996, AK292892, AK299655, M11058, and others.

Panther Classification:

Molecular Function -

oxidoreductase, reductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
ubiquinone metabolic process
steroid metabolic process
cholesterol metabolic process
positive regulation of cell proliferation
isoprenoid biosynthetic process
visual learning
embryo development
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
coenzyme A metabolic process
sterol biosynthetic process
positive regulation of stress-activated MAPK cascade
negative regulation of apoptotic process
negative regulation of MAP kinase activity
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade

Function(s)

hydroxymethylglutaryl-CoA reductase (NADPH) activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
hydroxymethylglutaryl-CoA reductase activity
protein homodimerization activity
NADP binding
coenzyme binding
protein phosphatase 2A binding
NADPH binding