MSS207624

• Gene Symbol: Pik3r1
• Gene Name: phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
• Gene Aliases: PI3K, p50alpha, p55alpha, p85alpha
• Chromosome Location: Chr.13: 101680761 - 101768217 on Build GRCm38
• UniGene ID: Mm.259333
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pik3r1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001024955.2	NP_001020126.1	4, 5	835
	NM_001077495.2	NP_001070963.1	10, 11	1924
GenBank mRNA	AK046259.1	-	4, 5	837
	BC026146.1	-	10, 11	1905	3979333
	BC051106.1	-	4, 5	535	5031261
	CB519962.1	-	4, 5	467
	M60651.1	-	10, 11	1859
	U50413.1	-	10, 11	1877

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_013005, XM_008760659, XM_006231868, D64048, D78486, and others.

Panther Classification:

Molecular Function -

kinase modulator

Gene Ontology Categories:

Process(es)

cellular glucose homeostasis
positive regulation of protein phosphorylation
negative regulation of cell-matrix adhesion
glucose metabolic process
protein phosphorylation
transport
negative regulation of cell adhesion
signal transduction
insulin receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of heart rate
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
phosphatidylinositol 3-kinase signaling
protein transport
negative regulation of cell-cell adhesion
B cell differentiation
positive regulation of cell migration
positive regulation of tumor necrosis factor production
response to insulin
cellular response to insulin stimulus
positive regulation of RNA splicing
cellular response to UV
response to endoplasmic reticulum stress
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
regulation of phosphatidylinositol 3-kinase activity
positive regulation of myoblast differentiation
negative regulation of osteoclast differentiation
negative regulation of blood pressure
negative regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
negative regulation of smooth muscle cell proliferation
protein stabilization
response to glucocorticoid
regulation of stress fiber assembly
NFAT protein import into nucleus
response to cAMP
growth hormone receptor signaling pathway
regulation of establishment of protein localization to plasma membrane
positive regulation of endoplasmic reticulum unfolded protein response

Function(s)

receptor binding
insulin receptor binding
insulin-like growth factor receptor binding
platelet-derived growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
calmodulin binding
protein C-terminus binding
transcription factor binding
1-phosphatidylinositol-3-kinase activity
protein kinase binding
protein phosphatase binding
protein domain specific binding
estrogen receptor binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
phosphatidylinositol 3-kinase regulator activity
phosphatidylinositol 3-kinase regulatory subunit binding
ErbB-3 class receptor binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
1-phosphatidylinositol-3-kinase regulator activity
protein heterodimerization activity
ATPase binding
phosphoprotein binding