MSS220207

• Gene Symbol: Smo
• Gene Name: smoothened homolog (Drosophila)
• Gene Aliases: E130215L21Rik, Smoh, bnb, smoothened
• Chromosome Location: Chr.6: 29735497 - 29761366 on Build GRCm38
• UniGene ID: Mm.29279
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Smo
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_176996.4	NP_795970.3	8, 9	1980
GenBank mRNA	AK081050.1	-	2, 3	168
	AK194911.1	-	4	372
	BC096028.1	-	8, 9	1499	6850065
	BQ947565.1	-	3, 4	242
	CA749812.1	-	5, 6	580
	FJ883552.1	-	8, 9	1489

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012807, U84402.

• Set Membership: G-protein coupled receptor

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ossification
vasculogenesis
osteoblast differentiation
in utero embryonic development
cell fate specification
neural crest cell migration
heart looping
positive regulation of neuroblast proliferation
positive regulation of mesenchymal cell proliferation
heart morphogenesis
determination of left/right asymmetry in lateral mesoderm
type B pancreatic cell development
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
smoothened signaling pathway
positive regulation of hh target transcription factor activity
multicellular organism development
determination of left/right symmetry
ventral midline determination
pattern specification process
central nervous system development
midgut development
positive regulation of cell proliferation
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
dentate gyrus development
cerebellar cortex morphogenesis
thalamus development
dorsal/ventral neural tube patterning
smoothened signaling pathway involved in ventral spinal cord patterning
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
central nervous system neuron differentiation
cerebral cortex development
negative regulation of epithelial cell differentiation
hair follicle morphogenesis
protein localization to nucleus
multicellular organism growth
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of DNA binding
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
astrocyte activation
cell development
digestive tract development
embryonic organ development
developmental growth
skeletal muscle fiber development
axon extension involved in axon guidance
forebrain morphogenesis
homeostasis of number of cells within a tissue
positive regulation of epithelial cell proliferation
protein stabilization
myoblast migration
negative regulation of hair follicle development
detection of cell density by contact stimulus involved in contact inhibition
atrial septum morphogenesis
mammary gland epithelial cell differentiation
epithelial-mesenchymal cell signaling
somite development
pancreas morphogenesis
left/right axis specification
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
positive regulation of branching involved in ureteric bud morphogenesis
regulation of stem cell population maintenance
regulation of heart morphogenesis

Function(s)

signal transducer activity
transmembrane signaling receptor activity
G-protein coupled receptor activity
patched binding
drug binding
Wnt-protein binding