MSS232169

• Gene Symbol: Irak3
• Gene Name: interleukin-1 receptor-associated kinase 3
• Gene Aliases: 4833428C18Rik, AI563835, IRAK-M
• Chromosome Location: Chr.10: 120141648 - 120201597 on Build GRCm38
• UniGene ID: Mm.146194
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Irak3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_028679.3	NP_082955.2	7	793
GenBank mRNA	AF461763.1	-	7	773
	AJ440757.2	-	7	715
	AK014783.1	-	7	844
	AK029057.1	-	7	794
	AK049210.1	-	7	824
	BC120829.1	-	7	754	40129752
	BC120831.1	-	7	754	40129754
	BC144835.1	-	7	754

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001108101, BC166731.

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
toll-like receptor signaling pathway
protein phosphorylation
apoptotic process
signal transduction
response to virus
positive regulation of macrophage tolerance induction
negative regulation of macrophage cytokine production
phosphorylation
cytokine-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
response to peptidoglycan
response to lipopolysaccharide
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
intracellular signal transduction
negative regulation of protein catabolic process
regulation of apoptotic process
negative regulation of protein complex disassembly
regulation of protein complex disassembly
response to exogenous dsRNA
negative regulation of MAP kinase activity
negative regulation of innate immune response
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
response to interleukin-1

Function(s)

nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
protein heterodimerization activity