MSS235749

• Gene Symbol: Abl1
• Gene Name: c-abl oncogene 1, non-receptor tyrosine kinase
• Gene Aliases: AI325092, Abl, E430008G22Rik, c-Abl
• Chromosome Location: Chr.2: 31688252 - 31807093 on Build GRCm38
• UniGene ID: Mm.1318
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Abl1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001112703.2	NP_001106174.1	6	2290
	NM_001283045.1	NP_001269974.1	6	1167
	NM_001283046.1	NP_001269975.1	7	2495
	NM_001283047.1	NP_001269976.1	7	2434
	NM_009594.4	NP_033724.2	6	1061
GenBank mRNA	AK088252.1	-	7	2420
	AK090095.1	-	6	1019
	AK166028.1	-	6	2279
	AK166210.1	-	7	2529
	BC059260.1	-	6	1088	6408990
	BC103770.1	-	6	1514	30848553
	CF536749.1	-	4	664
	CF727094.1	-	3	194
	CK626997.1	-	3	213
	J02995.1	-	6	1014
	L10656.1	-	4	615

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001100850, XM_006233918, XM_003749439, DQ294401, DQ294402.

Gene Ontology Categories:

Process(es)

B-1 B cell homeostasis
positive regulation of protein phosphorylation
B cell proliferation involved in immune response
transitional one stage B cell differentiation
DNA repair
protein phosphorylation
endocytosis
phagocytosis
autophagy
apoptotic process
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
response to oxidative stress
cell adhesion
epidermal growth factor receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
cerebellum morphogenesis
negative regulation of cell-cell adhesion
microspike assembly
actin cytoskeleton organization
negative regulation of BMP signaling pathway
regulation of actin cytoskeleton organization
positive regulation of osteoblast proliferation
substrate adhesion-dependent cell spreading
peptidyl-tyrosine autophosphorylation
B cell proliferation
signal transduction in response to DNA damage
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
negative regulation of mitotic cell cycle
positive regulation of mitotic cell cycle
alpha-beta T cell differentiation
platelet-derived growth factor receptor signaling pathway
spleen development
thymus development
collateral sprouting
positive regulation of peptidyl-tyrosine phosphorylation
activated T cell proliferation
B cell receptor signaling pathway
neuromuscular process controlling balance
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of oxidoreductase activity
negative regulation of ubiquitin-protein transferase activity
regulation of cell cycle
Bergmann glial cell differentiation
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
negative regulation of protein serine/threonine kinase activity
actin filament branching
positive regulation of interleukin-2 secretion
negative regulation of phospholipase C activity
positive regulation of neuron death
positive regulation of interferon-gamma secretion
regulation of extracellular matrix organization
positive regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of endothelial cell apoptotic process
regulation of cellular senescence
negative regulation of cellular senescence
regulation of response to DNA damage stimulus

Function(s)

nucleotide binding
magnesium ion binding
DNA binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
protein C-terminus binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
SH3 domain binding
protein kinase binding
protein domain specific binding
syntaxin binding
manganese ion binding
metal ion binding
actin filament binding
mitogen-activated protein kinase binding
proline-rich region binding
delta-catenin binding