MSS278683

• Gene Symbol: Vegfa
• Gene Name: vascular endothelial growth factor A
• Gene Aliases: Vegf, Vpf
• Chromosome Location: Chr.17: 46016993 - 46032377 on Build GRCm38
• UniGene ID: Mm.282184
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Vegfa
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001025250.3	NP_001020421.2	4	1345
	NM_001025257.3	NP_001020428.2	4	1345
	NM_001110266.1	NP_001103736.1	1	655
	NM_001110267.1	NP_001103737.1	1	655
	NM_001110268.1	NP_001103738.1	1	655
	NM_001287056.1	NP_001273985.1	4	1345
	NM_001287057.1	NP_001273986.1	4	1345
	NM_001287058.1	NP_001273987.1	4	1345
	NM_009505.4	NP_033531.3	4	1345
GenBank mRNA	AY120866.1	-	2	223
	AY707864.1	-	5	542
	AY750956.1	-	5	503
	AY750957.1	-	5	466
	AY756068.1	-	4	281
	BC061468.1	-	4	718	6816435
	BQ554097.1	-	1	300
	BQ832724.1	-	3	246
	EF028705.1	-	5	538
	M95200.1	-	4	410
	S37052.1	-	4	336
	S38083.1	-	4	336
	S38100.1	-	4	336

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001110335, NM_001110336, NM_001287114, NM_001110334, NM_031836, and others.

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
angiogenesis
ovarian follicle development
blood vessel development
patterning of blood vessels
response to hypoxia
in utero embryonic development
kidney development
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
vasculature development
lymphangiogenesis
blood vessel remodeling
sprouting angiogenesis
cell migration involved in sprouting angiogenesis
positive regulation of neuroblast proliferation
positive regulation of mesenchymal cell proliferation
positive regulation of receptor internalization
basophil chemotaxis
heart morphogenesis
outflow tract morphogenesis
coronary vein morphogenesis
regulation of transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
mesoderm development
lactation
cell proliferation
positive regulation of cell proliferation
regulation of cell shape
positive regulation of signal transduction
positive regulation of endothelial cell migration
positive regulation of gene expression
cell migration
negative regulation of cell-cell adhesion
cell differentiation
monocyte differentiation
macrophage differentiation
lung development
positive regulation of cell migration
regulation of cGMP metabolic process
epithelial cell differentiation
positive regulation of vascular endothelial growth factor receptor signaling pathway
post-embryonic camera-type eye development
positive regulation of protein complex assembly
positive regulation of protein autophosphorylation
activation of protein kinase activity
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
tube formation
endothelial cell chemotaxis
cellular response to vascular endothelial growth factor stimulus
lymph vessel morphogenesis
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor signaling pathway
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
VEGF-activated neuropilin signaling pathway
growth
T-helper 1 type immune response
eye photoreceptor cell development
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of vascular permeability
surfactant homeostasis
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
endothelial cell migration
regulation of endothelial cell differentiation
positive regulation of angiogenesis
negative regulation of bone resorption
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
mRNA stabilization
lung alveolus development
cell maturation
blood vessel morphogenesis
camera-type eye morphogenesis
positive regulation of smooth muscle cell proliferation
neuron development
cardiac muscle fiber development
branching morphogenesis of an epithelial tube
positive regulation of axon extension involved in axon guidance
artery morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of positive chemotaxis
induction of positive chemotaxis
positive regulation of cellular component movement
positive regulation of cell division
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
primitive erythrocyte differentiation
cell chemotaxis
lung vasculature development
mammary gland alveolus development
positive regulation of mast cell chemotaxis
cardiac vascular smooth muscle cell development
angiogenesis involved in coronary vascular morphogenesis
coronary artery morphogenesis
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of ERK1 and ERK2 cascade
cellular response to hypoxia
dopaminergic neuron differentiation
commissural neuron axon guidance
positive regulation of protein kinase C signaling
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of branching involved in ureteric bud morphogenesis
regulation of retinal ganglion cell axon guidance
positive regulation of peptidyl-tyrosine autophosphorylation
positive regulation of p38MAPK cascade
negative regulation of neuron death
positive regulation of lymphangiogenesis
regulation of hematopoietic progenitor cell differentiation
positive regulation of histone deacetylase activity
positive regulation of retinal ganglion cell axon guidance
positive regulation of protein localization to early endosome
positive regulation of protein kinase D signaling
positive regulation of receptor activity
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

fibronectin binding
receptor binding
cytokine activity
platelet-derived growth factor receptor binding
vascular endothelial growth factor receptor binding
protein binding
growth factor activity
heparin binding
neuropilin binding
chemoattractant activity
identical protein binding
protein homodimerization activity
vascular endothelial growth factor receptor 1 binding
vascular endothelial growth factor receptor 2 binding
protein heterodimerization activity
receptor agonist activity
extracellular matrix binding