RSS302775

• Gene Symbol: Tp53
• Gene Name: tumor protein p53
• Gene Aliases: Trp53, p53
• Chromosome Location: Chr.10: 56187013 - 56198449 on Build Rnor_6.0
• UniGene ID: Rn.54443
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tp53
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_030989.3	NP_112251.2	4, 5	490
	XM_006246594.2	XP_006246656.1	5, 6	919
	XM_006246595.2	XP_006246657.1	4, 5	1276
	XM_008767773.1	XP_008765995.1	4, 5	497
GenBank mRNA	AF209191.1	-	3, 4	382
	BC081788.1	-	4, 5	419	7193583
	BC098663.1	-	4, 5	448	7384467
	CV126174.1	-	4, 5	490
	FQ232659.1	-	4, 5	474
	U90328.1	-	3, 4	359
	X13058.1	-	3, 4	382

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001127233, NM_011640, AB017816, AK138777, EU031806, and others.

Panther Classification:

Molecular Function -

P53-like transcription factor

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
DNA strand renaturation
in utero embryonic development
somitogenesis
release of cytochrome c from mitochondria
T cell proliferation involved in immune response
B cell lineage commitment
T cell lineage commitment
positive regulation of leukocyte migration
response to ischemia
nucleotide-excision repair
double-strand break repair
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein complex assembly
apoptotic process
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
response to oxidative stress
ER overload response
cell cycle arrest
transforming growth factor beta receptor signaling pathway
Ras protein signal transduction
multicellular organism development
gastrulation
negative regulation of neuroblast proliferation
central nervous system development
aging
cell aging
protein localization
negative regulation of DNA replication
negative regulation of cell proliferation
determination of adult lifespan
rRNA transcription
response to UV
response to salt stress
embryo development ending in birth or egg hatching
response to inorganic substance
response to metal ion
response to X-ray
response to UV-B
response to organonitrogen compound
response to gamma radiation
positive regulation of cardiac muscle cell apoptotic process
response to organic cyclic compound
cerebellum development
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
negative regulation of transforming growth factor beta receptor signaling pathway
response to caffeine
positive regulation of histone deacetylation
chromatin assembly
mitotic G1 DNA damage checkpoint
positive regulation of protein oligomerization
response to retinoic acid
T cell differentiation in thymus
response to vitamin B3
response to cytokine
regulation of tissue remodeling
cellular response to heat
cellular protein localization
cellular response to UV
multicellular organism growth
cellular response to drug
positive regulation of mitochondrial membrane permeability
wound healing
regulation of cell proliferation
cellular response to glucose starvation
response to drug
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
entrainment of circadian clock by photoperiod
response to amino acid
mitochondrial DNA repair
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of cell cycle
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
negative regulation of fibroblast proliferation
circadian behavior
embryonic organ development
negative regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
regulation of catalytic activity
protein tetramerization
chromosome organization
neuron apoptotic process
regulation of intracellular pH
regulation of cell cycle
response to hyperoxia
regulation of thymocyte apoptotic process
positive regulation of thymocyte apoptotic process
necroptotic process
positive regulation of cell cycle arrest
cellular response to organonitrogen compound
cellular response to hypoxia
cellular response to ionizing radiation
mitotic cell cycle arrest
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of release of cytochrome c from mitochondria
positive regulation of cell aging
replicative senescence
oxidative stress-induced premature senescence
oligodendrocyte apoptotic process
negative regulation of macromitophagy
regulation of mitochondrial membrane permeability involved in apoptotic process
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
regulation of hydrogen peroxide-induced cell death
regulation of fibroblast apoptotic process
negative regulation of DNA biosynthetic process
negative regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
regulation of cellular senescence
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protease binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
copper ion binding
protein binding
ATP binding
protein C-terminus binding
transcription factor binding
enzyme binding
protein kinase binding
protein phosphatase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
histone deacetylase regulator activity
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
protein N-terminus binding
chaperone binding
protein phosphatase 2A binding
MDM2/MDM4 family protein binding