RSS318576

• Gene Symbol: Rapgef2
• Gene Name: Rap guanine nucleotide exchange factor (GEF) 2
• Gene Aliases: PDZ-GEF1, RA-GEF-1, nRap GEP
• Chromosome Location: Chr.2: 177836191 - 178057397 on Build Rnor_6.0
• UniGene ID: Rn.23121
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Rapgef2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001107684.1	NP_001101154.1	5	774
	XM_006232511.2	XP_006232573.2	9	2662
	XM_006232512.2	XP_006232574.1	7	1728
	XM_006232513.2	XP_006232575.1	7	1539
	XM_008761092.1	XP_008759314.1	13	2032
	XM_008761093.1	XP_008759315.1	12	2015
	XM_008761094.1	XP_008759316.1	13	2032
	XM_008761095.1	XP_008759317.1	13	1706
	XM_008761096.1	XP_008759318.1	11	2321
	XM_008761097.1	XP_008759319.1	10	2213
	XM_008761098.1	XP_008759320.1	10	3505

More Information

Panther Classification:

Molecular Function -

guanyl-nucleotide exchange factor

Gene Ontology Categories:

Process(es)

blood vessel development
neuron migration
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
small GTPase mediated signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
cAMP-mediated signaling
ventricular system development
forebrain neuron development
microvillus assembly
neuron projection development
brain-derived neurotrophic factor receptor signaling pathway
positive regulation of protein binding
Rap protein signal transduction
nerve growth factor signaling pathway
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
positive regulation of protein kinase activity
negative regulation of melanin biosynthetic process
regulation of synaptic plasticity
negative regulation of dendrite morphogenesis
regulation of small GTPase mediated signal transduction
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to cGMP
adenylate cyclase-activating adrenergic receptor signaling pathway
protein localization to plasma membrane
establishment of endothelial intestinal barrier
regulation of cell junction assembly
cellular response to nerve growth factor stimulus
positive regulation of cAMP-dependent protein kinase activity
positive regulation of dendritic cell apoptotic process
positive regulation of vasculogenesis
positive regulation of neuron migration

Function(s)

guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
Rap guanyl-nucleotide exchange factor activity
protein kinase binding
PDZ domain binding
cAMP binding
cGMP binding
beta-1 adrenergic receptor binding
WW domain binding
phosphatidic acid binding