RSS350228

• Gene Symbol: Klf4
• Gene Name: Kruppel-like factor 4 (gut)
• Gene Aliases: GKLF
• Chromosome Location: Chr.5: 72283311 - 72287669 on Build Rnor_6.0
• UniGene ID: Rn.7719
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Klf4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_053713.1	NP_446165.1	3	364
GenBank mRNA	AF390546.1	-	3	364
	BC085720.1	-	3	757	7190219

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_004235, AF022184, AK095134, U70663, AK313489, and others.

Panther Classification:

Molecular Function -

C2H2 zinc finger transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
epidermal cell differentiation
response to organic substance
negative regulation of phosphatidylinositol 3-kinase signaling
negative regulation of muscle hyperplasia
stem cell population maintenance
cell differentiation
post-embryonic camera-type eye development
negative regulation of NF-kappaB transcription factor activity
positive regulation of cellular protein metabolic process
response to retinoic acid
negative regulation of heterotypic cell-cell adhesion
post-embryonic hemopoiesis
regulation of cell proliferation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of phosphatidylinositol 3-kinase activity
negative regulation of interleukin-8 biosynthetic process
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hemoglobin biosynthetic process
negative regulation of smooth muscle cell proliferation
epidermis morphogenesis
positive regulation of protein metabolic process
negative regulation of protein kinase B signaling
positive regulation of telomerase activity
canonical Wnt signaling pathway
negative regulation of response to cytokine stimulus
cellular response to hydrogen peroxide
negative regulation of ERK1 and ERK2 cascade
cellular response to retinoic acid
cellular response to growth factor stimulus
cellular response to organic cyclic compound
cellular response to cycloheximide
cellular response to laminar fluid shear stress
negative regulation of cell migration involved in sprouting angiogenesis
cellular response to peptide
negative regulation of chemokine (C-X-C motif) ligand 2 production

Function(s)

core promoter proximal region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding transcription factor recruiting
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription cofactor binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
beta-catenin binding
transcription factor binding
phosphatidylinositol 3-kinase regulator activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
metal ion binding