RSS361484

• Gene Symbol: Spi1
• Gene Name: Spi-1 proto-oncogene
• Gene Aliases: Pu.1, Sfpi1
• Chromosome Location: Chr.3: 79918135 - 79937708 on Build Rnor_6.0
• UniGene ID: Rn.230674
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Spi1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005892.2	NP_001005892.1	5	827
	XM_006234532.2	XP_006234594.1	5	1706
GenBank mRNA	AB154364.1	-	5	690
	BC091185.1	-	5	827	7366435

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_003120, NM_001080547, X52056, BI519776, BM561863, and others.
This siRNA also targets the following transcripts in Mouse: NM_011355, AK153524, AK142246, M38252, M32370, and others.

Panther Classification:

Molecular Function -

winged helix/forkhead transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
vasculature development
lymphoid progenitor cell differentiation
myeloid leukocyte differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
lymphocyte differentiation
cell differentiation
erythrocyte differentiation
macrophage differentiation
granulocyte differentiation
somatic stem cell population maintenance
myeloid dendritic cell differentiation
histone H3 acetylation
hypermethylation of CpG island
negative regulation of MHC class II biosynthetic process
regulation of erythrocyte differentiation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure regression
cellular response to ethanol
negative regulation of histone H4 acetylation
apoptotic process involved in patterning of blood vessels

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
sequence-specific DNA binding
NFAT protein binding