RSS372686

• Gene Symbol: Dab2
• Gene Name: disabled 2, mitogen-responsive phosphoprotein
• Gene Aliases: Doc-2, Doc2
• Chromosome Location: Chr.2: 55747353 - 55768848 on Build Rnor_6.0
• UniGene ID: Rn.161784
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Dab2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_024159.1	NP_077073.1	4, 5	479
GenBank mRNA	AF045658.1	-	1, 2	126
	BC097314.1	-	4, 5	514	7444786
	FQ224185.1	-		789
	U95177.1	-	4, 5	479
	U95178.1	-	4, 5	479

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001037905, NM_023118, NM_001008702, NM_001102400, AK154716, and others.

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

cell morphogenesis involved in differentiation
in utero embryonic development
positive regulation of receptor recycling
positive regulation of protein phosphorylation
endocytosis
receptor-mediated endocytosis
pinocytosis
apoptotic process
integrin-mediated signaling pathway
activation of JUN kinase activity
endoderm development
excretion
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of neuron projection development
protein transport
Wnt signaling pathway
myeloid cell differentiation
negative regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of protein binding
positive regulation of aldosterone biosynthetic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of transcription elongation from RNA polymerase II promoter
leading edge cell differentiation
negative regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of endocytosis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
clathrin coat assembly
response to steroid hormone
negative regulation of epithelial cell proliferation
positive regulation of SMAD protein import into nucleus
negative regulation of androgen receptor signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to epidermal growth factor stimulus
cellular response to transforming growth factor beta stimulus
negative regulation of canonical Wnt signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
response to salt
negative regulation of protein localization to plasma membrane
positive regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of Rho-dependent protein serine/threonine kinase activity
positive regulation of clathrin-mediated endocytosis
positive regulation of early endosome to late endosome transport
positive regulation of aldosterone secretion
positive regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

integrin binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
protein C-terminus binding
clathrin binding
phosphatidylinositol binding
AP-2 adaptor complex binding
clathrin adaptor activity
cargo receptor activity
SMAD binding